RT Journal Article
T1 Spontaneous clearance of chronic hepatitis C is rare in HIV-infected patients after effective use of combination antiretroviral therapy.
A1 Frias, Mario
A1 Rivero-Juarez, Antonio
A1 Tellez, Francisco
A1 Perez-Perez, Monserrat
A1 Camacho, Angela
A1 Machuca, Isabel
A1 Lorenzo-Moncada, Sandra
A1 Lopez-Lopez, Pedro
A1 Rivero, Antonio
AB To evaluate the rate of spontaneous resolution of chronic hepatitis C (CHC) infection in a cohort of HIV-infected patients. A retrospective analysis of 509 HIV-infected patients with chronic HCV infection was performed at two reference hospitals in Andalusia. The main variable of the study was spontaneous clearance of CHC, defined as a negative HCV RNA result after at least two previous quantitative measurements of HCV RNA separated by a minimum of 12 months. Of 509 patients, 3 (0.59%; 95% CI: 0.15%-1.6%) experienced spontaneous clearance of CHC. After combination antiretroviral therapy (cART) initiation, two of three cases experienced an increased CD4+ count, coinciding with HCV viral clearance. All patients were IL28B CC carriers, 2 were co-infected with HCV genotype 3 (the HCV genotype of the remaining patient was not available). Spontaneous clearance of CHC is a rare event in the context of HIV/HCV co-infected patients and may be associated with the effective use of cART and thus HIV suppression.
PB Public Library of Science
YR 2017
FD 2017-04-21
LK http://hdl.handle.net/10668/11170
UL http://hdl.handle.net/10668/11170
LA en
NO Frias M, Rivero-Juarez A, Tellez F, Perez-Perez M, Camacho A, Machuca I, et al. Grupo de Estudio de Hepatitis Virales (HEPAVIR) of the Sociedad Andaluza de Enfermedades Infecciosas (SAEI). Spontaneous clearance of chronic hepatitis C is rare in HIV-infected patients after effective use of combination antiretroviral therapy. PLoS One. 2017 May 4;12(5):e0177141
DS RISalud
RD Apr 17, 2025