RT Journal Article
T1 Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care.
A1 Breiteneder, Heimo
A1 Diamant, Zuzana
A1 Eiwegger, Thomas
A1 Fokkens, Wytske J
A1 Traidl-Hoffmann, Claudia
A1 Nadeau, Kari
A1 O'Hehir, Robyn E
A1 O'Mahony, Liam
A1 Pfaar, Oliver
A1 Torres, Maria J
A1 Wang, De Yun
A1 Zhang, Luo
A1 Akdis, Cezmi A
K1 allergy
K1 exposome
K1 microbiome
K1 neuroimmune
K1 respiratory viral infections
AB The specialties of allergy and clinical immunology have entered the era of precision medicine with the stratification of diseases into distinct disease subsets, specific diagnoses, and targeted treatment options, including biologicals and small molecules. This article reviews recent developments in research and patient care and future trends in the discipline. The section on basic mechanisms of allergic diseases summarizes the current status and defines research needs in structural biology, type 2 inflammation, immune tolerance, neuroimmune mechanisms, role of the microbiome and diet, environmental factors, and respiratory viral infections. In the section on diagnostic challenges, clinical trials, precision medicine and immune monitoring of allergic diseases, asthma, allergic and nonallergic rhinitis, and new approaches to the diagnosis and treatment of drug hypersensitivity reactions are discussed in further detail. In the third section, unmet needs and future research areas for the treatment of allergic diseases are highlighted with topics on food allergy, biologics, small molecules, and novel therapeutic concepts in allergen-specific immunotherapy for airway disease. Unknowns and future research needs are discussed at the end of each subsection.
PB Wiley-Blackwell Publishing Ltd.
YR 2019
FD 2019-06-04
LK http://hdl.handle.net/10668/13915
UL http://hdl.handle.net/10668/13915
LA en
NO Breiteneder H, Diamant Z, Eiwegger T, Fokkens WJ, Traidl-Hoffmann C, Nadeau K, O'Hehir RE, O'Mahony L, Pfaar O, Torres MJ, Wang Y, Zhang L, Akdis CA. Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care. Allergy. 2019 Dec;74(12):2293-2311
DS RISalud
RD Apr 17, 2025