RT Journal Article
T1 Vertebral fractures in patients with inflammatory bowel disease compared with a healthy population: a prospective case-control study.
A1 Vázquez, Ma Angeles
A1 Lopez, Enrique
A1 Montoya, Ma José
A1 Giner, Mercè
A1 Pérez-Temprano, Ramón
A1 Pérez-Cano, Ramón
K1 Morphometric vertebral fractures
K1 Adrenal Cortex Hormones
K1 Inflammatory bowel disease
K1 Bone mineral density
K1 Bone remodeling
K1 Enfermedades óseas metabólicas
K1 Osteoporosis
K1 Estudios de casos y controles
K1 Enfermedad inflamatoria intestinal
K1 Fracturas de la columna vertebral
AB BACKGROUNDA prospective study was performed to compare the prevalence of morphometric vertebral fractures (MVF) between patients with inflammatory bowel disease (IBD) and healthy subjects and to identify predictive factors of fracture.METHODSA total of 107 patients with IBD (53 with Crohn's disease and 54 with ulcerative colitis) and 51 healthy subjects participated in the study. Information about anthropometric parameters, toxins, previous fractures, and parameters related to this disease were evaluated. The index of vertebral deformity, bone mass density (BMD), and biochemical parameters were calculated.RESULTSA total of 72 fractures were detected in 38.32% of patients with IBD, and 10 fractures were detected in 13.73% of healthy subjects; the risk of fracture in patients with IBD was higher than that in control subjects (OR, 4.03; 95% CI, 1.652-9.847; p < 0.002). We found no correlation between fracture and BMD in patients with IBD (lumbar spine, r = -0.103, p = 0.17 and femoral neck, r = -0.138, p = 0.07). Corticosteroid treatment was not associated with prevalent vertebral fractures nor with taking corticosteroids (r = 0.135, p = 0.14) or the duration for which they were taken (r = 0.08, p = 0.38), whereas this relationship was present in the controls (r = -0.365, p = 0.01). In the multivariate analysis, none of the measured parameters were significantly predictive of fracture, only to manifested IBD. Hypovitaminosis D was observed in 55.14% of patients with IBD.CONCLUSIONSThe prevalence of morphometric vertebral fractures is higher in patients with IBD than in the healthy population, without association with BMD or corticoid treatment. Simply having IBD was proven to be a predictive factor of fracture. We observed a high incidence of hypovitaminosis D in patients with IBD.
PB BioMed Central
YR 2012
FD 2012-05-14
LK http://hdl.handle.net/10668/1711
UL http://hdl.handle.net/10668/1711
LA en
NO Vázquez MA, Lopez E, Montoya MJ, Giner M, Pérez-Temprano R, Pérez-Cano R. Vertebral fractures in patients with inflammatory bowel disease compared with a healthy population: a prospective case-control study. BMC Gastroenterol. 2012 May 14; 12:47
NO Journal Article;
DS RISalud
RD Apr 6, 2025