RT Journal Article
T1 Cell Death Related Proteins Beyond Apoptosis in the CNS.
A1 Bahatyrevich-Kharitonik, Bazhena
A1 Medina-Guzman, Rafael
A1 Flores-Cortes, Alicia
A1 Garcia-Cruzado, Marta
A1 Kavanagh, Edel
A1 Burguillos, Miguel Angel
K1 Bcl-2
K1 Bcl-xL
K1 CNS
K1 caspase
K1 neurodegeneration
K1 non-apoptotic
K1 sexual dymorphism
AB Cell death related (CDR) proteins are a diverse group of proteins whose original function was ascribed to apoptotic cell death signaling. Recently, descriptions of non-apoptotic functions for CDR proteins have increased. In this minireview, we comment on recent studies of CDR proteins outside the field of apoptosis in the CNS, encompassing areas such as the inflammasome and non-apoptotic cell death, cytoskeleton reorganization, synaptic plasticity, mitophagy, neurodegeneration and calcium signaling among others. Furthermore, we discuss the evolution of proteomic techniques used to predict caspase substrates that could potentially explain their non-apoptotic roles. Finally, we address new concepts in the field of non-apoptotic functions of CDR proteins that require further research such the effect of sexual dimorphism on non-apoptotic CDR protein function and the emergence of zymogen-specific caspase functions.
PB Frontiers Research Foundation
SN 2296-634X
YR 2022
FD 2022-01-14
LK http://hdl.handle.net/10668/20526
UL http://hdl.handle.net/10668/20526
LA en
NO Bahatyrevich-Kharitonik B, Medina-Guzman R, Flores-Cortes A, García-Cruzado M, Kavanagh E, Burguillos MA. Cell Death Related Proteins Beyond Apoptosis in the CNS. Front Cell Dev Biol. 2022 Jan 14;9:825747.
DS RISalud
RD Apr 8, 2025