RT Journal Article
T1 Major Adverse Cardiovascular Events in Coronary Type 2 Diabetic Patients: Identification of Associated Factors Using Electronic Health Records and Natural Language Processing.
A1 Gonzalez-Juanatey, Carlos
A1 Anguita-Sanchez, Manuel
A1 Barrios, Vivencio
A1 Nuñez-Gil, Ivan
A1 Gomez-Doblas, Juan Jose
A1 Garcia-Moll, Xavier
A1 Lafuente-Gormaz, Carlos
A1 Rollan-Gomez, Maria Jesus
A1 Peral-Disdier, Vicente
A1 Martinez-Dolz, Luis
A1 Rodriguez-Santamarta, Miguel
A1 Viñolas-Prat, Xavier
A1 Soriano-Colome, Toni
A1 Muñoz-Aguilera, Roberto
A1 Plaza, Ignacio
A1 Curcio-Ruigomez, Alejandro
A1 Orts-Soler, Ernesto
A1 Segovia, Javier
A1 Fanjul, Víctor
A1 Cequier, Angel
K1 MACE
K1 Coronary artery disease
K1 Diabetes mellitus
K1 Electronic health records
K1 Natural language processing
K1 Risk factors
AB Patients with Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are at high risk of developing major adverse cardiovascular events (MACE). This is a multicenter, retrospective, and observational study performed in Spain aimed to characterize these patients in a real-world setting. Unstructured data from the Electronic Health Records were extracted by EHRead®, a technology based on Natural Language Processing and machine learning. The association between new MACE and the variables of interest were investigated by univariable and multivariable analyses. From a source population of 2,184,662 patients, we identified 4072 adults diagnosed with T2DM and CAD (62.2% male, mean age 70 ± 11). The main comorbidities observed included arterial hypertension, hyperlipidemia, and obesity, with metformin and statins being the treatments most frequently prescribed. MACE development was associated with multivessel (Hazard Ratio (HR) = 2.49) and single coronary vessel disease (HR = 1.71), transient ischemic attack (HR = 2.01), heart failure (HR = 1.32), insulin treatment (HR = 1.40), and percutaneous coronary intervention (PCI) (HR = 2.27), whilst statins (HR = 0.73) were associated with a lower risk of MACE occurrence. In conclusion, we found six risk factors associated with the development of MACE which were related with cardiovascular diseases and T2DM severity, and treatment with statins was identified as a protective factor for new MACE in this study.
PB MDPI
SN 2077-0383
YR 2022
FD 2022-10-22
LK http://hdl.handle.net/10668/21357
UL http://hdl.handle.net/10668/21357
LA en
NO González-Juanatey C, Anguita-Sánchez M, Barrios V, Núñez-Gil I, Gómez-Doblas JJ, García-Moll X, et al. Major Adverse Cardiovascular Events in Coronary Type 2 Diabetic Patients: Identification of Associated Factors Using Electronic Health Records and Natural Language Processing. J Clin Med. 2022 Oct 11;11(20):6004
DS RISalud
RD Jul 6, 2025