TY  - JOUR
AU  - Olivieri, Michele
AU  - Cho, Tiffany
AU  - Álvarez-Quilón, Alejandro
AU  - Li, Kejiao
AU  - Schellenberg, Matthew J
AU  - Zimmermann, Michal
AU  - Hustedt, Nicole
AU  - Rossi, Silvia Emma
AU  - Adam, Salomé
AU  - Melo, Henrique
AU  - Heijink, Anne Margriet
AU  - Sastre-Moreno, Guillermo
AU  - Moatti, Nathalie
AU  - Szilard, Rachel K
AU  - McEwan, Andrea
AU  - Ling, Alexanda K
AU  - Serrano-Benitez, Almudena
AU  - Ubhi, Tajinder
AU  - Feng, Sumin
AU  - Pawling, Judy
AU  - Delgado-Sainz, Irene
AU  - Ferguson, Michael W
AU  - Dennis, James W
AU  - Brown, Grant W
AU  - Cortés-Ledesma, Felipe
AU  - Williams, R Scott
AU  - Martin, Alberto
AU  - Xu, Dongyi
AU  - Durocher, Daniel
PY  - 2020
DO  - 10.1016/j.cell.2020.05.040
UR  - http://hdl.handle.net/10668/15917
T2  - Cell
AB  - The response to DNA damage is critical for cellular homeostasis, tumor suppression, immunity, and gametogenesis. In order to provide an unbiased and global view of the DNA damage response in human cells, we undertook 31 CRISPR-Cas9 screens against 27...
LA  - en
KW  - CRISPR
KW  - DNA damage
KW  - DNA repair
KW  - DNA-damaging agents
KW  - cancer therapeutics
KW  - functional genomics
KW  - genome stability
KW  - mechanism-of-action
KW  - Aminoquinolines
KW  - Animals
KW  - CRISPR-Cas Systems
KW  - Cell Line
KW  - Cytochrome-B(5) Reductase
KW  - DNA Damage
KW  - DNA Helicases
KW  - DNA Repair
KW  - DNA Topoisomerases, Type II
KW  - Gene Regulatory Networks
KW  - Humans
KW  - Mice
KW  - Picolinic Acids
KW  - RNA, Guide, Kinetoplastida
KW  - Tumor Suppressor Protein p53
TI  - A Genetic Map of the Response to DNA Damage in Human Cells.
TY  - research article
VL  - 182
ER  -