%0 Journal Article
%A Hilbrands, Luuk B
%A Duivenvoorden, Raphaël
%A Vart, Priya
%A Franssen, Casper F M
%A Hemmelder, Marc H
%A Jager, Kitty J
%A Kieneker, Lyanne M
%A Noordzij, Marlies
%A Pena, Michelle J
%A Vries, Hanne de
%A Arroyo, David
%A Covic, Adrian
%A Crespo, Marta
%A Goffin, Eric
%A Islam, Mahmud
%A Massy, Ziad A
%A Montero, Nuria
%A Oliveira, João P
%A Roca Muñoz, Ana
%A Sanchez, J Emilio
%A Sridharan, Sivakumar
%A Winzeler, Rebecca
%A Gansevoort, Ron T
%A ERACODA Collaborators
%T COVID-19-related mortality in kidney transplant and dialysis patients: results of the ERACODA collaboration.
%D 2020
%U https://hdl.handle.net/10668/24389
%X Patients on kidney replacement therapy comprise a vulnerable population and may be at increased risk of death from coronavirus disease 2019 (COVID-19). Currently, only limited data are available on outcomes in this patient population. We set up the ERACODA (European Renal Association COVID-19 Database) database, which is specifically designed to prospectively collect detailed data on kidney transplant and dialysis patients with COVID-19. For this analysis, patients were included who presented between 1 February and 1 May 2020 and had complete information available on the primary outcome parameter, 28-day mortality. Of the 1073 patients enrolled, 305 (28%) were kidney transplant and 768 (72%) dialysis patients with a mean age of 60 ± 13 and 67 ± 14 years, respectively. The 28-day probability of death was 21.3% [95% confidence interval (95% CI) 14.3-30.2%] in kidney transplant and 25.0% (95% CI 20.2-30.0%) in dialysis patients. Mortality was primarily associated with advanced age in kidney transplant patients, and with age and frailty in dialysis patients. After adjusting for sex, age and frailty, in-hospital mortality did not significantly differ between transplant and dialysis patients [hazard ratio (HR) 0.81, 95% CI 0.59-1.10, P = 0.18]. In the subset of dialysis patients who were a candidate for transplantation (n = 148), 8 patients died within 28 days, as compared with 7 deaths in 23 patients who underwent a kidney transplantation  The 28-day case-fatality rate is high in patients on kidney replacement therapy with COVID-19 and is primarily driven by the risk factors age and frailty. Furthermore, in the first year after kidney transplantation, patients may be at increased risk of COVID-19-related mortality as compared with dialysis patients on the waiting list for transplantation. This information is important in guiding clinical decision-making, and for informing the public and healthcare authorities on the COVID-19-related mortality risk in kidney transplant and dialysis patients.
%K COVID-19
%K dialysis
%K kidney
%K mortality
%K transplantation
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