RT Journal Article
T1 Long-Term Impact of an Educational Antimicrobial Stewardship Program on Management of Patients with Hematological Diseases.
A1 Guisado-Gil, Ana Belen
A1 Aguilar-Guisado, Manuela
A1 Peñalva, German
A1 Lepe, Jose Antonio
A1 Espigado, Ildefonso
A1 Rodriguez-Arboli, Eduardo
A1 Gonzalez-Campos, Jose
A1 Rodriguez-Torres, Nancy
A1 Montero-Cuadrado, Maria Isabel
A1 Falantes-Gonzalez, Jose Francisco
A1 Reguera-Ortega, Juan Luis
A1 Gil-Navarro, Maria Victoria
A1 Molina, Jose
A1 Perez-Simon, Jose-Antonio
A1 Cisneros, Jose Miguel
K1 anti-infective agents
K1 antimicrobial stewardship
K1 bacteremia
K1 candidemia
K1 hematologic diseases
AB Antimicrobial stewardship programs (ASPs) in hematological patients are especially relevant. However, information about ASPs in this population is scarce. For 11 years, we quarterly assessed antimicrobial consumption and incidence and death rates of multidrug-resistant (MDR) bloodstream infections (BSI) in the hematology Department. Healthcare activity indicators were also monitored yearly. We performed an interrupted time-series analysis. Antimicrobials showed a sustained reduction with a relative effect of -62.3% (95% CI -84.5 to -40.1) nine years after the inception of the ASP, being especially relevant for antifungals (relative effect -80.4%, -90.9 to -69.9), quinolones (relative effect -85.0%, -102.0 to -68.1), and carbapenems (relative effect -68.8%, -126.0 to -10.6). Incidence density of MDR BSI remained low and stable (mean 1.10 vs. 0.82 episodes per 1000 occupied bed days for the pre-intervention and the ASP period, respectively) with a quarterly percentage of change of -0.3% (95% CI -2.0 to 1.4). Early and late mortality of MDR BSI presented a steady trend (quarterly percentage of change -0.7%, 95% CI -1.7 to 0.3 and -0.6%, 95% CI -1.5 to 0.3, respectively). Volume and complexity of healthcare activity increased over the years. The ASP effectively achieved long-term reductions in antimicrobial consumption and improvements in the prescription profile, without increasing the mortality of MDR BSI.
PB MDPI AG
SN 2079-6382
YR 2021
FD 2021-01-30
LK http://hdl.handle.net/10668/17156
UL http://hdl.handle.net/10668/17156
LA en
NO Guisado-Gil AB, Aguilar-Guisado M, Peñalva G, Lepe JA, Espigado I, Rodríguez-Arbolí E, et al. Long-Term Impact of an Educational Antimicrobial Stewardship Program on Management of Patients with Hematological Diseases. Antibiotics (Basel). 2021 Jan 30;10(2):136.
DS RISalud
RD Apr 7, 2025