RT Journal Article
T1 A Narrative Review of Cell-Based Approaches for Cranial Bone Regeneration.
A1 Falguera Uceda, Maria I
A1 Sánchez-Casanova, Silvia
A1 Escudero-Duch, Clara
A1 Vilaboa, Nuria
K1 biomaterials
K1 cell therapy
K1 cranial bone
K1 gene therapy
AB Current cranial repair techniques combine the use of autologous bone grafts and biomaterials. In addition to their association with harvesting morbidity, autografts are often limited by insufficient quantity of bone stock. Biomaterials lead to better outcomes, but their effectiveness is often compromised by the unpredictable lack of integration and structural failure. Bone tissue engineering offers the promising alternative of generating constructs composed of instructive biomaterials including cells or cell-secreted products, which could enhance the outcome of reconstructive treatments. This review focuses on cell-based approaches with potential to regenerate calvarial bone defects, including human studies and preclinical research. Further, we discuss strategies to deliver extracellular matrix, conditioned media and extracellular vesicles derived from cell cultures. Recent advances in 3D printing and bioprinting techniques that appear to be promising for cranial reconstruction are also discussed. Finally, we review cell-based gene therapy approaches, covering both unregulated and regulated gene switches that can create spatiotemporal patterns of transgenic therapeutic molecules. In summary, this review provides an overview of the current developments in cell-based strategies with potential to enhance the surgical armamentarium for regenerating cranial vault defects.
SN 1999-4923
YR 2022
FD 2022-01-05
LK http://hdl.handle.net/10668/21538
UL http://hdl.handle.net/10668/21538
LA en
DS RISalud
RD Apr 7, 2025