RT Journal Article
T1 Changes in Body Composition in Anorexia Nervosa: Predictors of Recovery and Treatment Outcome.
A1 Agüera, Zaida
A1 Romero, Xandra
A1 Arcelus, Jon
A1 Sánchez, Isabel
A1 Riesco, Nadine
A1 Jiménez-Murcia, Susana
A1 González-Gómez, Jana
A1 Granero, Roser
A1 Custal, Nuria
A1 Montserrat-Gil de Bernabé, Mónica
A1 Tárrega, Salomé
A1 Baños, Rosa M
A1 Botella, Cristina
A1 Torre, Rafael de la
A1 Fernández-García, José C
A1 Fernández-Real, José M
A1 Frühbeck, Gema
A1 Gómez-Ambrosi, Javier
A1 Tinahones, Francisco J
A1 Crujeiras, Ana B
A1 Casanueva, Felipe F
A1 Menchón, José M
A1 Fernández-Aranda, Fernando
K1 Anorexia nerviosa
K1 Tejido adiposo
K1 Metabolismo basal
K1 Trastorno por atracón
K1 Composición corporal
K1 Índice de masa corporal
K1 Agua corporal
K1 Impedancia eléctrica
K1 Metas
K1 Humanos
K1 Femenino
K1 Modelos logísticos
K1 Resultado del tratamiento
AB The restoration of body composition (BC) parameters is considered to be one of the most important goals in the treatment of patients with anorexia nervosa (AN). However, little is known about differences between AN diagnostic subtypes [restricting (AN-R) and binge/purging (AN-BP)] and weekly changes in BC during refeeding treatment. Therefore, the main objectives of our study were twofold: 1) to assess the changes in BC throughout nutritional treatment in an AN sample and 2) to analyze predictors of BC changes during treatment, as well as predictors of treatment outcome. The whole sample comprised 261 participants [118 adult females with AN (70 AN-R vs. 48 AN-BP), and 143 healthy controls]. BC was measured weekly during 15 weeks of day-hospital treatment using bioelectrical impedance analysis (BIA). Assessment measures also included the Eating Disorders Inventory-2, as well as a number of other clinical indices. Overall, the results showed that AN-R and AN-BP patients statistically differed in all BC measures at admission. However, no significant time×group interaction was found for almost all BC parameters. Significant time×group interactions were only found for basal metabolic rate (p = .041) and body mass index (BMI) (p = .035). Multiple regression models showed that the best predictors of pre-post changes in BC parameters (namely fat-free mass, muscular mass, total body water and BMI) were the baseline values of BC parameters. Stepwise predictive logistic regressions showed that only BMI and age were significantly associated with outcome, but not with the percentage of body fat. In conclusion, these data suggest that although AN patients tended to restore all BC parameters during nutritional treatment, only AN-BP patients obtained the same fat mass values as healthy controls. Put succinctly, the best predictors of changes in BC were baseline BC values, which did not, however, seem to influence treatment outcome.
PB Public Library of Science
YR 2015
FD 2015-11
LK http://hdl.handle.net/10668/2168
UL http://hdl.handle.net/10668/2168
LA en
NO Agüera Z, Romero X, Arcelus J, Sánchez I, Riesco N, Jiménez-Murcia S, et al. Changes in Body Composition in Anorexia Nervosa: Predictors of Recovery and Treatment Outcome. PLoS ONE; 10(11):e0143012
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD May 17, 2025