RT Journal Article
T1 Metalloproteinases 1 and 3 as Potential Biomarkers in Breast Cancer Development
A1 Argote Camacho, Angela Ximena
A1 González Ramírez, Amanda Rocío
A1 Pérez Alonso, Alejandro José
A1 Rejón García, Juan David
A1 Olivares Urbano, María Auxiliadora
A1 Torné Poyatos, Pablo
A1 Ríos Arrabal, Sandra
A1 Núñez, María Isabel
K1 Breast cancer
K1 Metalloproteinases
K1 Immunohistochemical expression
K1 Epithelial-to-mesenchymal transition (EMT)
K1 Biomarkers
K1 Diagnostic factors
K1 Extracellular matrix
K1 MMPs
K1 MMP inhibitors
K1 Linfedema del cáncer de mama
K1 Metaloproteasas
K1 Biomarcadores
K1 Matriz extracelular
K1 Metaloproteinasas de la matriz
K1 Inhibidores de la metaloproteinasa de la matriz
AB Breast cancer continues to be one of the main causes of morbidity and mortality globally and was the leading cause of cancer death in women in Spain in 2020. Early diagnosis is one of the most effective methods to lower the incidence and mortality rates of breast cancer. The human metalloproteinases (MMP) mainly function as proteolytic enzymes degrading the extracellular matrix and plays important roles in most steps of breast tumorigenesis. This retrospective cohort study shows the immunohistochemical expression levels of MMP-1, MMP-2, MMP-3, and MMP-9 in 154 women with breast cancer and 42 women without tumor disease. The samples of breast tissue are assessed using several tissue matrices (TMA). The percentages of staining (≤50%->50%) and intensity levels of staining (weak, moderate, or intense) are considered. The immunohistochemical expression of the MMP-1-intensity (p = 0.043) and MMP-3 percentage (p = 0.018) and intensity, (p = 0.025) present statistically significant associations with the variable group (control-case); therefore, expression in the tumor tissue samples of these MMPs may be related to the development of breast cancer. The relationships between these MMPs and some clinicopathological factors in breast cancer are also evaluated but no correlation is found. These results suggest the use of MMP-1 and MMP-3 as potential biomarkers of breast cancer diagnosis.
PB MDPI
YR 2021
FD 2021-08-20
LK http://hdl.handle.net/10668/3520
UL http://hdl.handle.net/10668/3520
LA en
NO Argote Camacho AX, González Ramírez AR, Pérez Alonso AJ, Rejón García JD, Olivares Urbano MA, Torné Poyatos P, et al. Metalloproteinases 1 and 3 as Potential Biomarkers in Breast Cancer Development.  International Journal of Molecular Sciences, vol. 22, no. 16, Aug. 2021.
DS RISalud
RD Apr 5, 2025