RT Journal Article
T1 Goat whey ameliorates intestinal inflammation on acetic acid-induced colitis in rats.
A1 Araújo, Daline Fernandes de Souza
A1 Guerra, Gerlane Coelho Bernardo
A1 Júnior, Raimundo Fernandes de Araújo
A1 Antunes de Araújo, Aurigena
A1 Antonino de Assis, Paloma Oliveira
A1 Nunes de Medeiros, Ariosvaldo
A1 Formiga de Sousa, Yasmim Regis
A1 Pintado, Maria Manuela Estevez
A1 Gálvez, Julio
A1 Queiroga, Rita de Cássia Ramos do Egypto
K1 cytokines
K1 goat whey
K1 immunohistochemical
K1 intestinal inflammation
K1 oxidative stress
AB Complementary or alternative medicine is of great interest for the treatment of inflammatory bowel disease, with the aim of ameliorating the side effects of the drugs commonly used or improving their efficacy. In this study, we evaluated the ability of goat whey to prevent intestinal inflammation in the experimental model of acetic acid-induced rats and compared it to sulfasalazine. Pretreatment with goat whey (1, 2, and 4g/kg) and sulfasalazine (250mg/kg) on colitic rats improved colonic inflammatory markers, including myeloperoxidase activity, leukotriene B4 levels, as well as the production of proinflammatory cytokines IL-1β and tumor necrosis factor-α. Furthermore, the administration of goat whey significantly reduced the colonic oxidative stress by reducing malondialdehyde levels and increased total glutathione content, a potent antioxidant peptide. The histological evaluation of the colonic specimens from colitic rats confirmed these beneficial effects, as goat whey preserved the colonic tissue, especially in those rats treated with the highest dose of goat whey or with sulfasalazine. The immunohistochemistry analysis of the colonic tissue evaluation also revealed a reduction in the expression of cyclooxygenase-2, inducible nitric oxide synthase, and matrix metalloproteinase-9, together with an increased expression of suppressor of cytokine signaling-1. These results suggest that goat whey exerted a preventive effect against the intestinal damage induced by acetic acid, showing a similar efficacy to that shown by sulfasalazine, therefore making it a potential treatment for human inflammatory bowel disease.
YR 2016
FD 2016-10-19
LK http://hdl.handle.net/10668/10556
UL http://hdl.handle.net/10668/10556
LA en
NO Araújo DFS, Guerra GCB, Júnior RFA, Antunes de Araújo A, Antonino de Assis PO, Nunes de Medeiros A,et al. Goat whey ameliorates intestinal inflammation on acetic acid-induced colitis in rats. J Dairy Sci. 2016 Dec;99(12):9383-9394.
DS RISalud
RD Apr 9, 2025