RT Journal Article
T1 Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia.
A1 Holubiec, Mariana I
A1 Romero, Juan I
A1 Suarez, Juan
A1 Portavella, Manuel
A1 Fernandez-Espejo, Emilio
A1 Blanco, Eduardo
A1 Galeano, Pablo
A1 de Fonseca, Fernando Rodriguez
K1 Astrogliosis
K1 Memory impairment
K1 Neonatal anoxia-ischemia
K1 Neuroinflammation
K1 Oleoylethanolamide
K1 Palmitoylethanolamide
AB Neonatal anoxia-ischemia (AI) particularly affects the central nervous system. Despite the many treatments that have been tested, none of them has proven to be completely successful. Palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) are acylethanolamides that do not bind to CB1 or CB2 receptors and thus they do not present cannabinoid activity. These molecules are agonist compounds of peroxisome proliferator-activator receptor alpha (PPARα), which modulates the expression of different genes that are related to glucose and lipid metabolism, inflammation, differentiation and proliferation. In the present study, we analyzed the effects that the administration of PEA or OEA, after a neonatal AI event, has over different areas of the hippocampus. To this end, 7-day-old rats were subjected to AI and then treated with vehicle, OEA (2 or 10 mg/kg) or PEA (2 or 10 mg/kg). At 30 days of age, animals were subjected to behavioral tests followed by immunohistochemical studies. Results showed that neonatal AI was associated with decreased locomotion, as well as recognition and spatial memory impairments. Furthermore, these deficits were accompanied with enhanced neuroinflammation and astrogliosis, as well as a decreased PPARα expression. PEA treatment was able to prevent neuroinflammation, reduce astrogliosis and preserve cognitive functions. These results indicate that the acylethanolamide PEA may play an important role in the mechanisms underlying neonatal AI, and it could be a good candidate for further studies regarding neonatal AI treatments.
PB Springer
YR 2018
FD 2018-07-23
LK http://hdl.handle.net/10668/12771
UL http://hdl.handle.net/10668/12771
LA en
NO Holubiec MI, Romero JI, Suárez J, Portavella M, Fernández-Espejo E, Blanco E, et al. Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia. Psychopharmacology (Berl). 2018 Oct;235(10):2929-2945
NO This work was supported by grants from FundacióBLa Marató de TV3^ (386/C/2011), European Regional DevelopmentFunds-European Union (ERDF-EU; Subprograma RETICS Red deTrastornos Adictivos RD16/0017/0001), Ministerio de Economía yCompetitividad and ISCIII (PI16/01689) to FRF; Own Plan of theAndalucía TECH, International Campus of Excellence (ICE) to PG, andgrants to EFE and FRF from Junta de Andalucía, Spain (EFE, group BIO 127; FRF, group BIO-339). JS holds a BMiguel Servet II^ research con tract from the National System of Health, ISCIII, EU-ERDF (CPII17/00024). Mariana I. Holubiec is a fellowship holder from AgenciaNacional de Promoción Científica y Tecnológica (ANPCyT, Argentina).Eduardo Blanco is an associate professor of the Serra-Hunter Programmefrom the Catalan Government. Juan I. Romero and Pablo Galeano areresearch members from Consejo Nacional de Investigaciones Científicasy Técnicas (CONICET, Argentina)
DS RISalud
RD Apr 7, 2025