RT Journal Article
T1 Systolic Blood Pressure and Outcomes in Stable Outpatients with Recent Symptomatic Artery Disease: A Population-Based Longitudinal Study.
A1 Sánchez Muñoz-Torrero, Juan F
A1 Escudero-Sánchez, Guillermo
A1 Calderón-García, Julián F
A1 Rico-Martín, Sergio
A1 Robles, Nicolás Roberto
A1 Bacaicoa, M Asunción
A1 Alcalá-Pedrajas, José N
A1 Gil-Fernández, Guadalupe
A1 Monreal, Manuel
A1 On Behalf Of The Frena Investigators, 
K1 death
K1 ischemic event
K1 outcomes
K1 symptomatic artery disease
K1 systolic blood pressure
AB The most appropriate targets for systolic blood pressure (SBP) levels to reduce cardiovascular morbidity and mortality in patients with symptomatic artery disease remain controversial. We compared the rate of subsequent ischemic events or death according to mean SBP levels during follow-up. Prospective cohort study. FRENA is an ongoing registry of stable outpatients with symptomatic coronary (CAD), cerebrovascular (CVD) or peripheral artery disease (PAD). 24 Spanish hospitals. 4789 stable outpatients with vascular disease. As of June 2017, 4789 patients had been enrolled in different Spanish centres. Of these, 1722 (36%) had CAD, 1383 (29%) CVD and 1684 (35%) PAD. Over a mean follow-up of 18 months, 136 patients suffered subsequent myocardial infarction, 125 had ischemic stroke, 74 underwent limb amputation, and 260 died. On multivariable analysis, CVD patients with mean SBP levels 130-140 mm Hg had a lower risk of mortality than those with levels 140 mm Hg (HR: 0.46; 95% CI: 0.26-0.84). PAD patients with mean SBP levels >140 mm Hg had a lower risk for subsequent ischemic events (HR: 0.57; 95% CI: 0.39-0.83) and those with levels 130-140 mm Hg (HR: 0.47; 95% CI: 0.29-0.78) or >140 mm Hg (HR: 0.32; 95% CI: 0.21-0.50) had a lower risk of mortality. We found no differences in patients with CAD. In this real-world cohort of symptomatic arterial disease patients, most of whom are not eligible for clinical trials, the risk of subsequent events and death varies according to the levels of SBP and the location of previous events. Especially among patients with large artery atherosclerosis, PAD or CVD, SBP
YR 2021
FD 2021-09-04
LK https://hdl.handle.net/10668/25954
UL https://hdl.handle.net/10668/25954
LA en
DS RISalud
RD Apr 17, 2025