RT Journal Article
T1 Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome.
A1 Valle-Hita, Cristina
A1 Becerra-Tomas, Nerea
A1 Diaz-Lopez, Andres
A1 Vazquez-Ruiz, Zenaida
A1 Megias, Isabel
A1 Corella, Dolores
A1 Goday, Albert
A1 Martinez, J Alfredo
A1 Alonso-Gomez, Angel M
A1 Warnberg, Julia
A1 Vioque, Jesus
A1 Romaguera, Dora
A1 Lopez-Miranda, Jose
A1 Estruch, Ramon
A1 Tinahones, Francisco J
A1 Lapetra, Jose
A1 Serra-Majem, Lluis
A1 Bueno-Cavanillas, Aurora
A1 Tur, Josep A
A1 Martín-Sanchez, Vicente
A1 Pinto, Xavier
A1 Gaforio, Jose J
A1 Matia-Martin, Pilar
A1 Vidal, Josep
A1 Amengual-Galbarte, Angela
A1 Daimiel, Lidia
A1 Ros, Emilio
A1 Garcia-Arellano, Ana
A1 Barragan, Rocio
A1 Fito, Montse
A1 Peña-Orihuela, Patricia J
A1 Asencio-Aznar, Alberto
A1 Gomez-Gracia, Enrique
A1 Martinez-Urbistondo, Diego
A1 Morey, Marga
A1 Casas, Rosa
A1 Garrido-Garrido, Eva Maria
A1 Tojal-Sierra, Lucas
A1 Damas-Fuentes, Miguel
A1 Goñi, Estibaliz
A1 Ortega-Azorin, Carolina
A1 Castañer, Olga
A1 Garcia-Rios, Antonio
A1 Gisbert-Selles, Cristina
A1 Sayon-Orea, Carmen
A1 Schroder, Helmut
A1 Salas-Salvado, Jordi
A1 Babio, Nancy
K1 Albuminuria
K1 Chronic kidney disease (CKD)
K1 Dietary acid load
K1 Glomerular filtration rate (GFR)
K1 Kidney function
K1 Net endogenous acid production (NEAP)
K1 Potential renal acid load (PRAL)
K1 Renal nutrition
AB Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). Older adults with overweight/obesity and metabolic syndrome (mean age 65 ± 5 years, 48% women) from the PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline from a food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year-changes in eGFR and UACR were set as the primary outcomes. We secondarily assessed ≥ 10% eGFR decline or ≥10% UACR increase. After multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, β: -0.64 ml/min/1.73 m2; 95% CI: -1.21 to -0.08 and NEAP, β: -0.56 ml/min/1.73 m2; 95% CI: -1.13 to 0.01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing ≥10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07-1.54 and NEAP, OR: 1.24; 95% CI: 1.03-1.50) and ≥10 % UACR increase (PRAL, OR: 1.23; 95% CI: 1.04-1.46) compared to individuals with lower dietary acid load. Higher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweight/obesity and metabolic syndrome.
PB Frontiers Research Foundation
SN 2296-861X
YR 2022
FD 2022-09-02
LK http://hdl.handle.net/10668/20676
UL http://hdl.handle.net/10668/20676
LA en
NO Valle-Hita C, Becerra-Tomás N, Díaz-López A, Vázquez-Ruiz Z, Megías I, Corella D, et al. Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome. Front Nutr. 2022 Sep 30;9:986190
NO The authors would especially like to thank the PREDIMEDPlus participants for their enthusiastic collaboration, the PREDIMED-Plus personnel for their outstanding support and the personnel of affiliated primary care centers for their exceptional effort. CIBEROBN, CIBERESP, and CIBERDEMare initiatives of ISCIII, Madrid, Spain. We also thank the PREDIMED-Plus Biobank Network, part of the National Biobank Platform of the ISCIII for storing and managing the PREDIMED-Plus biological samples.
DS RISalud
RD May 12, 2025