%0 Journal Article
%A Valle-Hita, Cristina
%A Becerra-Tomas, Nerea
%A Diaz-Lopez, Andres
%A Vazquez-Ruiz, Zenaida
%A Megias, Isabel
%A Corella, Dolores
%A Goday, Albert
%A Martinez, J Alfredo
%A Alonso-Gomez, Angel M
%A Warnberg, Julia
%A Vioque, Jesus
%A Romaguera, Dora
%A Lopez-Miranda, Jose
%A Estruch, Ramon
%A Tinahones, Francisco J
%A Lapetra, Jose
%A Serra-Majem, Lluis
%A Bueno-Cavanillas, Aurora
%A Tur, Josep A
%A Martín-Sanchez, Vicente
%A Pinto, Xavier
%A Gaforio, Jose J
%A Matia-Martin, Pilar
%A Vidal, Josep
%A Amengual-Galbarte, Angela
%A Daimiel, Lidia
%A Ros, Emilio
%A Garcia-Arellano, Ana
%A Barragan, Rocio
%A Fito, Montse
%A Peña-Orihuela, Patricia J
%A Asencio-Aznar, Alberto
%A Gomez-Gracia, Enrique
%A Martinez-Urbistondo, Diego
%A Morey, Marga
%A Casas, Rosa
%A Garrido-Garrido, Eva Maria
%A Tojal-Sierra, Lucas
%A Damas-Fuentes, Miguel
%A Goñi, Estibaliz
%A Ortega-Azorin, Carolina
%A Castañer, Olga
%A Garcia-Rios, Antonio
%A Gisbert-Selles, Cristina
%A Sayon-Orea, Carmen
%A Schroder, Helmut
%A Salas-Salvado, Jordi
%A Babio, Nancy
%T Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome.
%D 2022
%@ 2296-861X
%U http://hdl.handle.net/10668/20676
%X Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). Older adults with overweight/obesity and metabolic syndrome (mean age 65 ± 5 years, 48% women) from the PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline from a food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year-changes in eGFR and UACR were set as the primary outcomes. We secondarily assessed ≥ 10% eGFR decline or ≥10% UACR increase. After multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, β: -0.64 ml/min/1.73 m2; 95% CI: -1.21 to -0.08 and NEAP, β: -0.56 ml/min/1.73 m2; 95% CI: -1.13 to 0.01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing ≥10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07-1.54 and NEAP, OR: 1.24; 95% CI: 1.03-1.50) and ≥10 % UACR increase (PRAL, OR: 1.23; 95% CI: 1.04-1.46) compared to individuals with lower dietary acid load. Higher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweight/obesity and metabolic syndrome.
%K Albuminuria
%K Chronic kidney disease (CKD)
%K Dietary acid load
%K Glomerular filtration rate (GFR)
%K Kidney function
%K Net endogenous acid production (NEAP)
%K Potential renal acid load (PRAL)
%K Renal nutrition
%~