RT Journal Article
T1 One-Year Changes in Urinary Microbial Phenolic Metabolites and the Risk of Type 2 Diabetes-A Case-Control Study.
A1 Marhuenda-Muñoz, María
A1 Domínguez-López, Inés
A1 Laveriano-Santos, Emily P
A1 Parilli-Moser, Isabella
A1 Razquin, Cristina
A1 Ruiz-Canela, Miguel
A1 Basterra-Gortari, Francisco Javier
A1 Corella, Dolores
A1 Salas-Salvadó, Jordi
A1 Fitó, Montserrat
A1 Lapetra, José
A1 Arós, Fernando
A1 Fiol, Miquel
A1 Serra-Majem, Lluis
A1 Pintó, Xavier
A1 Gómez-Gracia, Enrique
A1 Ros, Emilio
A1 Estruch, Ramon
A1 Lamuela-Raventós, Rosa M
K1 Mediterranean diet
K1 PREDIMED study
K1 bioactive compounds
K1 cardiovascular
K1 liquid chromatography
K1 mass spectrometry
K1 phytochemicals
K1 urinary microbial phenolic metabolites
AB The intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association between one-year changes in urinary microbial phenolic metabolites (MPM) and the incidence of type 2 diabetes, we performed a case-control study using data and samples of the PREDIMED trial including 46 incident type 2 diabetes cases of 172 randomly selected participants. Eight urinary MPMs were quantified in urine by liquid chromatography coupled to mass spectrometry and used to assess their associations with type 2 diabetes risk by multivariable logistic regression models. Compared to participants in the lowest tertile of one-year changes in hydroxybenzoic acid glucuronide, those in the highest tertile had a significantly lowered probability of developing type 2 diabetes (OR [95% CI], 0.39 [0.23−0.64]; p
SN 2076-3921
YR 2022
FD 2022-08-08
LK http://hdl.handle.net/10668/20787
UL http://hdl.handle.net/10668/20787
LA en
DS RISalud
RD Apr 9, 2025