%0 Journal Article
%A Marhuenda-Muñoz, María
%A Domínguez-López, Inés
%A Laveriano-Santos, Emily P
%A Parilli-Moser, Isabella
%A Razquin, Cristina
%A Ruiz-Canela, Miguel
%A Basterra-Gortari, Francisco Javier
%A Corella, Dolores
%A Salas-Salvadó, Jordi
%A Fitó, Montserrat
%A Lapetra, José
%A Arós, Fernando
%A Fiol, Miquel
%A Serra-Majem, Lluis
%A Pintó, Xavier
%A Gómez-Gracia, Enrique
%A Ros, Emilio
%A Estruch, Ramon
%A Lamuela-Raventós, Rosa M
%T One-Year Changes in Urinary Microbial Phenolic Metabolites and the Risk of Type 2 Diabetes-A Case-Control Study.
%D 2022
%@ 2076-3921
%U http://hdl.handle.net/10668/20787
%X The intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association between one-year changes in urinary microbial phenolic metabolites (MPM) and the incidence of type 2 diabetes, we performed a case-control study using data and samples of the PREDIMED trial including 46 incident type 2 diabetes cases of 172 randomly selected participants. Eight urinary MPMs were quantified in urine by liquid chromatography coupled to mass spectrometry and used to assess their associations with type 2 diabetes risk by multivariable logistic regression models. Compared to participants in the lowest tertile of one-year changes in hydroxybenzoic acid glucuronide, those in the highest tertile had a significantly lowered probability of developing type 2 diabetes (OR [95% CI], 0.39 [0.23−0.64]; p
%K Mediterranean diet
%K PREDIMED study
%K bioactive compounds
%K cardiovascular
%K liquid chromatography
%K mass spectrometry
%K phytochemicals
%K urinary microbial phenolic metabolites
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