TY - JOUR AU - Sarni, Dan AU - Barroso, Sonia AU - Shtrikman, Alon AU - Irony-Tur Sinai, Michal AU - Oren, Yifat S AU - Aguilera, Andrés AU - Kerem, Batsheva PY - 2022 DO - 10.1016/j.celrep.2022.111397 UR - http://hdl.handle.net/10668/22077 T2 - Cell reports AB - DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads to DNA damage and genomic instability. Replication stress is commonly associated with slow and stalled replication forks.... LA - en KW - CP: Molecular biology KW - DNA replication KW - R loops KW - genomic instability KW - oncogenes KW - replication stress KW - topoisomerase 1 KW - DNA KW - DNA Damage KW - DNA Replication KW - Genomic Instability KW - Humans KW - R-Loop Structures KW - RNA TI - Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability. TY - research article VL - 40 ER -