RT Journal Article T1 Correlation between Biomarkers of Pain in Saliva and PAINAD Scale in Elderly People with Cognitive Impairment and Inability to Communicate A1 Cantón-Habas, Vanesa A1 Rich-Ruiz, Manuel A1 Moreno-Casbas, María Teresa A1 Ramírez-Expósito, María Jesús A1 Martínez-Martos, Jose Manuel A1 Carrera-González, María Del Pilar K1 Dementia K1 Pain K1 Pain assessment in advanced dementia K1 Biomarkers K1 Nursing K1 Demencia K1 Dolor K1 Medida del dolor K1 Biomarcadores K1 Enfermería AB The pain assessment in advanced dementia (PAINAD) appears to be a clinically useful tool. However, the salivary determination of tumor necrosis factor receptor type II (sTNF-RII) and secretory IgA (sIgA) as pain biomarkers is still incipient. The aim was to correlate the PAINAD score with sTNF-RII and sIgA biomarker levels in the saliva of patients with advanced dementia. In this regard, a cross-sectional study was conducted. The sample consisted of 75 elderly patients with a clinical diagnosis of dementia and a global deterioration scale (GDS) score of 5 to 7. The PAINAD scale was determined by a previously trained professional and the collection of salivary samples was performed using the passive secretion method. Human sTNF-RII and sIgA using ELISA kits. The results showed a correlation between the PAINAD scale (numeric, binary, and recoded) and sTNF-RII and sIgA (p < 0.001). No association between the sociodemographic and clinical variables and the PAINAD scale was found (p > 0.05). Between 97.3% and 96.2% of patients with pain on the PAINAD scale also showed pain based on the sTNF-RII levels; in all of them, sIgA levels did not fit the logistic models. Therefore, the correlation highlights the usefulness of this scale and confirms the usefulness of sTNF-RII and sIgA as biomarkers of pain. PB MDPI YR 2021 FD 2021-04-01 LK http://hdl.handle.net/10668/4510 UL http://hdl.handle.net/10668/4510 LA en NO Cantón-Habas V, Rich-Ruiz M, Moreno-Casbas MT, Ramírez-Expósito MJ, Martínez-Martos JM, Carrera-González MDP. Correlation between Biomarkers of Pain in Saliva and PAINAD Scale in Elderly People with Cognitive Impairment and Inability to Communicate. J Clin Med. 2021 Apr 1;10(7):1424 DS RISalud RD Mar 14, 2025