RT Journal Article
T1 Antituberculosis drug resistance in isolates of Mycobacterium tuberculosis complex in southeast Spain.
A1 Montiel Quezel-Guerraz, Natalia
A1 Sanchez-Porto, Antonio
A1 Ortega Torres, Maria
A1 Perez Santos, Mª Jesus
A1 Acosta, Federico
A1 Guzman, Antonio
A1 Correa Ruiz, Ana
A1 Bermudez Ruiz, Pilar
K1 Extensively drug-resistant
K1 Genotype
K1 Isoniazid resistance
K1 Molecular detection
K1 Multidrug-resistant
K1 Tuberculosis
AB The aim of this study was to determine resistance to antituberculosis (anti-TB) drugs in Mycobacterium tuberculosis complex isolates from patients diagnosed with Tuberculosis (TB) in southeast Spain and to study related epidemiological factors. This retrospective study analysed 5-year data (2012-2016) obtained in southeast Spain for a total equivalent population of 1 735 608 inhabitants. Clinical samples were examined from 557 patients with suspected pulmonary TB (n=470; 84.4%) or extrapulmonary TB (n=87; 15.6%), taking into account patient age, sex, human immunodeficiency virus (HIV) infection, country of birth and prior anti-TB treatment. TB was found more frequently in men than in women (66.6% vs. 33.4%), and the age group with the most cases (43.7%) was 36-55 years. Among the first-line anti-TB drugs, 7.0% of patients harboured isolates resistant to isoniazid (INH) and 1.6% to rifampicin (RIF); moreover, 1.4% of isolates were multidrug-resistant TB (MDR-TB) and 0.7% were extensively drug-resistant TB. There was a statistically significant relationship (P=0.028) between MDR-TB isolates and non-Spanish-born patients, but not between the latter and INH resistance. Resistance to INH and RIF was observed at levels similar to those published nationwide, with rates of MDR-TB being somewhat lower. Rates of HIV/TB co-infection have decreased considerably between 2012 and 2016.
PB Elsevier
YR 2019
FD 2019-08-02
LK http://hdl.handle.net/10668/14406
UL http://hdl.handle.net/10668/14406
LA en
NO Montiel Quezel-Guerraz N, Sánchez-Porto A, Ortega Torres M, Pérez Santos MJ, Acosta F, Guzman A, et al. Antituberculosis drug resistance in isolates of Mycobacterium tuberculosis complex in southeast Spain. J Glob Antimicrob Resist. 2020 Mar;20:183-186
DS RISalud
RD Apr 17, 2025