TY - JOUR AU - Garcia, María Angel AU - Carrasco, Esther AU - Aguilera, Margarita AU - Alvarez, Pablo AU - Rivas, Carmen AU - Campos, Joaquín Maria AU - Prados, José Carlos AU - Calleja, Miguel Angel AU - Esteban, Mariano AU - Marchal, Juan Antonio AU - Aranega, Antonia PY - 2011 DO - 10.1371/journal.pone.0023887 UR - http://hdl.handle.net/10668/406 T2 - PLoS One AB - The chemotherapeutic drug 5-FU is widely used in the treatment of a range of cancers, but resistance to the drug remains a major clinical problem. Since defects in the mediators of apoptosis may account for chemo-resistance, the identification of new... LA - en PB - Public Library of Science KW - Antimetabolitos Antineoplásicos KW - Neoplasias de la Mama KW - Línea Celular Tumoral KW - Neoplasias del Colon KW - Femenino KW - Fluorouracil KW - Humanos KW - Fosforilación KW - eIF-2 Quinasa KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antimetabolites::Antimetabolites, Antineoplastic KW - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms KW - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor KW - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Colonic Neoplasms KW - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Pyrimidinones::Uracil::Fluorouracil KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Phosphorylation KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::eIF-2 Kinase TI - The Chemotherapeutic Drug 5-Fluorouracil Promotes PKR-Mediated Apoptosis in a p53-Independent Manner in Colon and Breast Cancer Cells TY - research article ER -