TY  - JOUR
AU  - Garcia, María Angel
AU  - Carrasco, Esther
AU  - Aguilera, Margarita
AU  - Alvarez, Pablo
AU  - Rivas, Carmen
AU  - Campos, Joaquín Maria
AU  - Prados, José Carlos
AU  - Calleja, Miguel Angel
AU  - Esteban, Mariano
AU  - Marchal, Juan Antonio
AU  - Aranega, Antonia
PY  - 2011
DO  - 10.1371/journal.pone.0023887
UR  - http://hdl.handle.net/10668/406
T2  - PLoS One
AB  - The chemotherapeutic drug 5-FU is widely used in the treatment of a range of cancers, but resistance to the drug remains a major clinical problem. Since defects in the mediators of apoptosis may account for chemo-resistance, the identification of new...
LA  - en
PB  - Public Library of Science
KW  - Antimetabolitos Antineoplásicos
KW  - Neoplasias de la Mama
KW  - Línea Celular Tumoral
KW  - Neoplasias del Colon
KW  - Femenino
KW  - Fluorouracil
KW  - Humanos
KW  - Fosforilación
KW  - eIF-2 Quinasa
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antimetabolites::Antimetabolites, Antineoplastic
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Colonic Neoplasms
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Pyrimidinones::Uracil::Fluorouracil
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Phosphorylation
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::eIF-2 Kinase
TI  - The Chemotherapeutic Drug 5-Fluorouracil Promotes PKR-Mediated Apoptosis in a p53-Independent Manner in Colon and Breast Cancer Cells
TY  - research article
ER  -