RT Journal Article
T1 Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness.
A1 Gil-Cosano, Jose J
A1 Gracia-Marco, Luis
A1 Ubago-Guisado, Esther
A1 Labayen, Idoia
A1 Adelantado-Renau, Mireia
A1 Cadenas-Sanchez, Cristina
A1 Mora-Gonzalez, Jose
A1 Plaza-Florido, Abel
A1 Aguilera, Concepcion M
A1 Gomez-Vida, Jose
A1 Maldonado, Jose
A1 Jurimae, Jaak
A1 Ortega, Francisco B
AB To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity. Plasma interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), epidermal growth factor, vascular endothelial growth factor A (VEGF), and C-reactive protein were analyzed in 55 children aged 8-11 years. A muscular fitness score was computed. Bone mineral content (BMC) of the total body-less head (TBLH) and lumbar spine (LS) were assessed using dual-energy x-ray absorptiometry. IL-6 (β = -0.136) and VEGF (β = -0.099) were associated with TBLH BMC, while TNF-α (β = -0.345) and IL-1β (β = 0.212) were associated with LS BMC (P  IL-6, VEGF, TNF-α, and IL-1β are significantly associated with bone mass. Higher muscular fitness may attenuate the adverse effect of high VEGF and TNF-α on bone mass.
PB nature
YR 2019
FD 2019-08-16
LK http://hdl.handle.net/10668/14481
UL http://hdl.handle.net/10668/14481
LA en
DS RISalud
RD Apr 6, 2025