RT Journal Article
T1 Effects of cyclic parenteral nutrition on parenteral-associated liver dysfunction parameters
A1 Arenas Villafranca, Jose J.
A1 Nieto Guindo, Miriam
A1 Alvaro Sanz, Elena
A1 Moreno Santamaria, Manuela
A1 Garrido Siles, Marga
A1 Abiles, Jimena
K1 Liver dysfunction
K1 Parenteral nutrition
K1 Cyclic parenteral nutrition
K1 Liver parameters
K1 Complications
K1 Cholestasis
K1 Taurine
AB Introduction: One of the most common complications of parenteral nutrition (PN) is liver dysfunction (LD). Therapeutic approaches for LD include, among others, administering cyclic parenteral nutrition (cPN), allowing some hours for metabolic rest. The purpose of this study was to evaluate the effectiveness of cPN in treating PN-associated LD.Materials and methods: A retrospective observational study was carried out at the Costa del Sol Hospital in Spain between 2013 and 2014. The study involved inpatients >= 18 years old prescribed with cPN due to the development of PN-associated LD. The hepatic biochemical parameters measured at baseline and after completion of cPN included aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP) and total bilirubin (TB). Quantitative values (age, biochemical parameters) were compared using matched Student's t-test; the mean change in qualitative variables (sex, indication of PN, hepatic comorbidities, presence of insulin in cPN, infection during cPN, management of LD prior to cPN administrarion) was estimated using Mann-Whitney U test, and bivariate correlation between quantitative variables was determined by Spearman's coefficient of correlation.Results: Thirty-seven patients met inclusion criteria. All hepatic function parameters except ALP improved after the administration of cPN, with statistically significant differences (p = 18 years old prescribed with cPN due to the development of PN-associated LD. The hepatic biochemical parameters measured at baseline and after completion of cPN included aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP) and total bilirubin (TB). Quantitative values (age, biochemical parameters) were compared using matched Student's t-test; the mean change in qualitative variables (sex, indication of PN, hepatic comorbidities, presence of insulin in cPN, infection during cPN, management of LD prior to cPN administrarion) was estimated using Mann-Whitney U test, and bivariate correlation between quantitative variables was determined by Spearman's coefficient of correlation.Results: Thirty-seven patients met inclusion criteria. All hepatic function parameters except ALP improved after the administration of cPN, with statistically significant differences (p
PB Bmc
YR 2017
FD 2017-10-04
LK http://hdl.handle.net/10668/19129
UL http://hdl.handle.net/10668/19129
LA en
DS RISalud
RD Jul 2, 2025