RT Journal Article
T1 European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 2. Treatment.
A1 Stratigos, Alexander J
A1 Garbe, Claus
A1 Dessinioti, Clio
A1 Lebbe, Celeste
A1 Bataille, Veronique
A1 Bastholt, Lars
A1 Dreno, Brigitte
A1 Concetta Fargnoli, Maria
A1 Forsea, Ana M
A1 Frenard, Cecille
A1 Harwood, Catherine A
A1 Hauschild, Axel
A1 Hoeller, Christoph
A1 Kandolf-Sekulovic, Lidija
A1 Kaufmann, Roland
A1 Kelleners-Smeets, Nicole W J
A1 Malvehy, Josep
A1 Del Marmol, Veronique
A1 Middleton, Mark R
A1 Moreno-Ramirez, David
A1 Pellecani, Giovanni
A1 Peris, Ketty
A1 Saiag, Philippe
A1 van den Beuken-van Everdingen, Marieke H J
A1 Vieira, Ricardo
A1 Zalaudek, Iris
A1 Eggermont, Alexander M M
A1 Grob, Jean-Jacques
A1 European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
K1 Anti-PD-1 antibody
K1 Cemiplimab
K1 Chemotherapy
K1 Cutaneous squamous cell carcinoma
K1 EGFR inhibitors
K1 Follow-up
K1 Locally advanced
K1 Metastatic
K1 Radiotherapy
K1 Surgical excision
K1 Treatment
AB In order to update recommendations on treatment, supportive care, education and follow-up of patients with invasive cutaneous squamous cell carcinoma (cSCC), a multidisciplinary panel of experts from the European Dermatology Forum, the European Association of Dermato-Oncology and the European Organization of Research and Treatment of Cancer was formed. Recommendations were based on evidence-based literature review, guidelines and expert consensus. Treatment recommendations are presented for common primary cSCC (low risk, high risk), locally advanced cSCC, regional metastatic cSCC (operable or inoperable) and distant metastatic cSCC. For common primary cSCC (the most frequent cSCC type), first-line treatment is surgical excision with postoperative margin assessment or microscopically controlled sugery. Safety margins containing clinical normal-appearing tissue around the tumour during surgical excision and negative margins as reported in the pathology report are necessary to minimise the risk of local recurrence and metastasis. In case of positive margins, a re-excision shall be done, for operable cases. Lymph node dissection is recommended for cSCC with cytologically or histologically confirmed regional nodal involvement. Radiotherapy should be considered as curative treatment for inoperable cSCC, or for non-surgical candidates. Anti-PD-1 antibodies are the first-line systemic treatment for patients with metastatic or locally advanced cSCC who are not candidates for curative surgery or radiation, with cemiplimab being the first approved systemic agent for advanced cSCC by the Food and Drug Administration/European Medicines Agency. Second-line systemic treatments for advanced cSCC include epidermal growth factor receptor inhibitors (cetuximab) combined with chemotherapy or radiation therapy. Multidisciplinary board decisions are mandatory for all patients with advanced disease who require more than surgery. Patients should be engaged with informed decisions on management and be provided with best supportive care to optimise symptom management and improve quality of life. Frequency of follow-up visits and investigations for subsequent new cSCC depend on underlying risk characteristics.
YR 2020
FD 2020-02-26
LK http://hdl.handle.net/10668/15184
UL http://hdl.handle.net/10668/15184
LA en
DS RISalud
RD May 11, 2025