TY - JOUR AU - Ceña-Diez, Rafael AU - Martin-Moreno, Alba AU - de la Mata, F Javier AU - Gomez-Ramirez, Rafael AU - Muñoz, Eduardo AU - Ardoy, Manuel AU - Muñoz-Fernández, Mª Angeles PY - 2019 DO - 10.2147/IJN.S188495 UR - http://hdl.handle.net/10668/13896 T2 - International journal of nanomedicine AB - HIV-1 and herpes simplex virus type-2 (HSV-2) represent two of the most relevant sexually transmitted diseases (STDs) worldwide. Moreover, each year there are >200 million pregnancies worldwide, and more than half are unintended. Continued high rates... LA - en PB - Dove Medical Press KW - G1-S4 dendrimer KW - G2-S16 dendrimer KW - HIV-1 KW - HSV-2 KW - Platycodin D KW - topical microbicide KW - Animals KW - Anti-Infective Agents KW - Cell Proliferation KW - Chlorocebus aethiops KW - Contraceptive Agents KW - Dendrimers KW - Female KW - Herpesvirus 2, Human KW - Humans KW - Leukocytes, Mononuclear KW - Male KW - Mice, Inbred BALB C KW - Saponins KW - Silanes KW - Sperm Capacitation KW - Spermatozoa KW - Toxicity Tests KW - Triterpenes KW - Vagina KW - Vero Cells TI - G1-S4 or G2-S16 carbosilane dendrimer in combination with Platycodin D as a promising vaginal microbicide candidate with contraceptive activity. TY - research article VL - 14 ER -