RT Journal Article
T1 Molecular and Clinical Implications of Somatostatin Receptor Profile and Somatostatin Analogues Treatment in Oral Cavity Squamous Cell Carcinoma
A1 Sanjuan-Sanjuan, Alba
A1 Alors-Perez, Emilia
A1 Sanchez-Frías, Marina
A1 Dean-Ferrer, Alicia
A1 Gahete, Manuel D.
A1 Heredero-Jung, Susana
A1 Luque, Raúl M.
K1 Somatostatin receptors
K1 Oral cavity cancer
K1 Head and neck
K1 Biomarkers
K1 Somatostatin analogues
K1 Therapeutic tool
K1 lanreotide
K1 Octreotide
K1 Pasireotide
K1 Oral squamous cell carcinoma
K1 Cell proliferation
K1 Receptores de somatostatina
K1 Neoplasias de la boca
K1 Biomarcadores
K1 Octreótido
K1 Carcinoma de células escamosas de cabeza y cuello
K1 Proliferación celular
AB Oral squamous cell carcinoma (OSCC) incidence has increased by 50% over the last decade. Unfortunately, surgery and adjuvant radiotherapy and chemotherapy are still the mainstream modality of treatment, underscoring the need for alternative therapies. Somatostatin-analogues (SSA) are efficacious and safe treatments for a variety of tumors, but the presence of somatostatin-receptors (SSTs) and pharmacological effects of SSA on OSCC are poorly known. In this study, we demonstrated that SST2 and SST3 levels were significantly higher in OSCC, compared to adjacent healthy control tissues. SST2 expression was associated with less regional metastasis and a lower recurrence rate. Moreover, SST2 was elevated in OSCC and associated with histopathological good prognosis factors, such as high peritumoral inflammation, smaller depth of invasion, and expansive vs. infiltrative front of tumor invasion. Importantly, treatment with different SSA (octreotide, lanreotide, and pasireotide) significantly reduced cell-proliferation in OSCC primary cell cultures. Altogether, this study demonstrated that SST2 is overexpressed in OSCC vs. healthy tissues and could represent a novel prognostic biomarker, since its expression is associated with tumors that show better prognostic factors and less recurrent rate. Moreover, our data unveil clear antitumoral effects of SSAs on OSCC, opening new avenues to explore their potential as targeting therapy to OSCC.
PB MDPI
YR 2021
FD 2021-09-27
LK http://hdl.handle.net/10668/4442
UL http://hdl.handle.net/10668/4442
LA en
NO Sanjuan-Sanjuan A, Alors-Perez E, Sanchez-Frías M, Dean-Ferrer A, Gahete MD, Heredero-Jung S, et al. Molecular and Clinical Implications of Somatostatin Receptor Profile and Somatostatin Analogues Treatment in Oral Cavity Squamous Cell Carcinoma. Cancers. 2021 Sep 27;13(19):4828
DS RISalud
RD Apr 11, 2025