RT Journal Article
T1 Novel Polymorphic Cocrystals of the Non-Steroidal Anti-Inflammatory Drug Niflumic Acid: Expanding the Pharmaceutical Landscape.
A1 Acebedo-Martínez, Francisco Javier
A1 Alarcón-Payer, Carolina
A1 Frontera, Antonio
A1 Barbas, Rafael
A1 Prohens, Rafel
A1 Di Crisci, Milena
A1 Domínguez-Martín, Alicia
A1 Gómez-Morales, Jaime
A1 Choquesillo-Lazarte, Duane
K1 NSAIDs
K1 caffeine
K1 cocrystal polymorphism
K1 mechanochemical synthesis
K1 niflumic acid
AB Any time the pharmaceutical industry develops a new drug, potential polymorphic events must be thoroughly described, because in a crystalline pharmaceutical solid, different arrangements of the same active pharmaceutical ingredient can yield to very different physicochemical properties that might be crucial for its efficacy, such as dissolution, solubility, or stability. Polymorphism in cocrystal formulation cannot be neglected, either. In this work, two different cocrystal polymorphs of the non-steroidal anti-inflammatory drug niflumic acid and caffeine are reported. They have been synthesized by mechanochemical methods and thoroughly characterized in solid-state by powder and single crystal X-ray diffraction respectively, as well as other techniques such as thermal analyses, infrared spectroscopy and computational methods. Both theoretical and experimental results are in agreement, confirming a conformational polymorphism. The polymorph NIF-CAF Form I exhibits improved solubility and dissolution rate compared to NIF-CAF Form II, although Form II is significantly more stable than Form I. The conditions needed to obtain these polymorphs and their transition have been carefully characterized, revealing an intricate system.
SN 1999-4923
YR 2021
FD 2021-12-13
LK https://hdl.handle.net/10668/26326
UL https://hdl.handle.net/10668/26326
LA en
DS RISalud
RD Apr 11, 2025