RT Journal Article
T1 Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) Trial.
A1 Zheng, Yan
A1 Hu, Frank B
A1 Ruiz-Canela, Miguel
A1 Clish, Clary B
A1 Dennis, Courtney
A1 Salas-Salvado, Jordi
A1 Hruby, Adela
A1 Liang, Liming
A1 Toledo, Estefania
A1 Corella, Dolores
A1 Ros, Emilio
A1 Fitó, Montserrat
A1 Gómez-Gracia, Enrique
A1 Arós, Fernando
A1 Fiol, Miquel
A1 Lapetra, José
A1 Serra-Majem, Lluis
A1 Estruch, Ramón
A1 Martínez-González, Miguel A
K1 cardiovascular disease
K1 diet
K1 dietary clinical trial
K1 epidemiology
K1 glutamate
K1 glutamine
K1 incidence
K1 stroke
AB Glutamate metabolism may play a role in the pathophysiology of cardiometabolic disorders. However, there is limited evidence of an association between glutamate-related metabolites and, moreover, changes in these metabolites, and risk of cardiovascular disease (CVD). Plasma levels of glutamate and glutamine were measured at baseline and 1-year follow-up in a case-cohort study including 980 participants (mean age 68 years; 46% male) from the PREvención con DIeta MEDiterránea (PREDIMED) randomized trial, which assessed a Mediterranean diet intervention in the primary prevention of CVD. During median 4.8 years of follow-up, there were 229 incident CVD events (nonfatal stroke, nonfatal myocardial infarction, or CVD death). In fully adjusted models, per 1-SD, baseline glutamate was associated with 43% (95% CI: 16% to 76%) and 81% (39% to 137%) increased risk of composite CVD and stroke alone, respectively, and baseline glutamine-to-glutamate ratio with 25% (6% to 40%) and 44% (25% to 58%) decreased risk of composite CVD and stroke alone, respectively. Associations appeared linear for stroke (both Plinear trend≤0.005). Among participants with high baseline glutamate, the interventions lowered CVD risk by 37% compared to the control diet; the intervention effects were not significant when baseline glutamate was low (Pinteraction=0.02). No significant effect of the intervention on year-1 changes in metabolites was observed, and no effect of changes themselves on CVD risk was apparent. Baseline glutamate was associated with increased CVD risk, particularly stroke, and glutamine-to-glutamate ratio was associated with decreased risk. Participants with high glutamate levels may obtain greater benefits from the Mediterranean diet than those with low levels. URL: www.controlled-trials.com. Unique identifier: ISRCTN 35739639.
YR 2016
FD 2016-09-15
LK http://hdl.handle.net/10668/10447
UL http://hdl.handle.net/10668/10447
LA en
DS RISalud
RD Apr 14, 2025