TY - JOUR AU - de Diego-Otero, Yolanda AU - Calvo-Medina, Rocio AU - Quintero-Navarro, Carolina AU - Sánchez-Salido, Lourdes AU - García-Guirado, Francisco AU - del Arco-Herrera, Ignacio AU - Fernández-Carvajal, Isabel AU - Ferrando-Lucas, Teresa AU - Caballero-Andaluz, Rafaela AU - Pérez-Costillas, Lucia PY - 2014 DO - 10.1186/1745-6215-15-345 UR - http://hdl.handle.net/10668/2095 T2 - Trials AB - BACKGROUNDFragile X syndrome (FXS) is an inherited neurodevelopmental condition characterised by behavioural, learning disabilities, physical and neurological symptoms. In addition, an important degree of comorbidity with autism is also present.... LA - en PB - BioMed Central KW - Antioxidants KW - Experimental treatment KW - Fragile X syndrome KW - Oxidative stress KW - Trial KW - Síndrome del cromosoma X frágil KW - Ácido ascórbico KW - Alfa-tocoferol KW - España KW - Resultado del tratamiento KW - Masculino KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Adolescent Behavior KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Human Development::Adolescent Development KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers KW - Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Data Collection::Checklist KW - Medical Subject Headings::Named Groups::Persons::Age Groups::Child KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Child Behavior KW - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Human Development::Child Development KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Clinical Protocols KW - Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition KW - Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Drug Combinations KW - Medical Subject Headings::Diseases::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Congenital Abnormalities::Chromosome Disorders::Sex Chromosome Disorders::Fragile X Syndrome KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Check Tags::Male KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Pilot Projects KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design KW - Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain KW - Medical Subject Headings::Phenomena and Processes::Physical Phenomena::Time::Time Factors KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome KW - Medical Subject Headings::Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Aptitude Tests::Intelligence Tests::Wechsler Scales KW - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Benzopyrans::Vitamin E::Tocopherols::alpha-Tocopherol KW - Medical Subject Headings::Named Groups::Persons::Age Groups::Adolescent TI - A combination of ascorbic acid and α-tocopherol to test the effectiveness and safety in the fragile X syndrome: study protocol for a phase II, randomized, placebo-controlled trial. TY - research article ER -