RT Journal Article
T1 Immunocompromised Patients with Protracted COVID-19: a Review of "Long Persisters".
A1 Dioverti, Veronica
A1 Salto-Alejandre, Sonsoles
A1 Haidar, Ghady
K1 COVID-19
K1 Immunocompromised
K1 Prolonged COVID-19
K1 Prolonged shedding
K1 SARS-CoV2
AB Certain immunocompromised individuals are at risk for protracted COVID-19, in which SARS-CoV-2 leads to a chronic viral infection. However, the pathogenesis, diagnosis, and management of this phenomenon remain ill-defined. Herein, we review key aspects of protracted SARS-CoV-2 infection in immunocompromised individuals, or the so-called long persisters, and describe the clinical presentation, risk factors, diagnosis, and treatment modalities of this condition, as well as intra-host viral evolution. Based on the available data, we also propose a framework of criteria with which to  approach this syndrome. Protracted COVID-19 is an uncharacterized syndrome affecting patients with B-cell depletion; our proposed diagnostic approach and definitions will inform much needed future research.
PB Springer
SN 2196-3029
YR 2022
FD 2022-11-12
LK http://hdl.handle.net/10668/21731
UL http://hdl.handle.net/10668/21731
LA en
NO Dioverti V, Salto-Alejandre S, Haidar G. Immunocompromised Patients with Protracted COVID-19: a Review of "Long Persisters". Curr Transplant Rep. 2022;9(4):209-218
DS RISalud
RD Apr 8, 2025