%0 Journal Article
%A Dioverti, Veronica
%A Salto-Alejandre, Sonsoles
%A Haidar, Ghady
%T Immunocompromised Patients with Protracted COVID-19: a Review of "Long Persisters".
%D 2022
%@ 2196-3029
%U http://hdl.handle.net/10668/21731
%X Certain immunocompromised individuals are at risk for protracted COVID-19, in which SARS-CoV-2 leads to a chronic viral infection. However, the pathogenesis, diagnosis, and management of this phenomenon remain ill-defined. Herein, we review key aspects of protracted SARS-CoV-2 infection in immunocompromised individuals, or the so-called long persisters, and describe the clinical presentation, risk factors, diagnosis, and treatment modalities of this condition, as well as intra-host viral evolution. Based on the available data, we also propose a framework of criteria with which to  approach this syndrome. Protracted COVID-19 is an uncharacterized syndrome affecting patients with B-cell depletion; our proposed diagnostic approach and definitions will inform much needed future research.
%K COVID-19
%K Immunocompromised
%K Prolonged COVID-19
%K Prolonged shedding
%K SARS-CoV2
%~