RT Journal Article
T1 Age-adjusted NT-proBNP could help in the early identification and follow-up of children at risk for severe multisystem inflammatory syndrome associated with COVID-19 (MIS-C)
A1 Rodriguez-Gonzalez, Moises
A1 Castellano-Martinez, Ana
K1 Multisystem inflammatory syndrome associated with COVID-19
K1 COVID-19
K1 SARS-CoV-2
K1 NT-proBNP
K1 Echocardiography
K1 Myocardial dysfunction
K1 Children
K1 Heart-failure
K1 Disease
K1 Performance
K1 Biomarkers
K1 Markers
K1 Society
K1 Values
AB BACKGROUND Multisystem inflammatory syndrome in children (MIS-C) has emerged as a new disease associated with COVID-19 that presents in acute critically ill children with acute cardiovascular dysfunction. AIM To determine whether the age-adjusted N-terminal pro-brain natriuretic peptide (NT-proBNP) value (Z-log-NT-proBNP) is associated with severe MIS-C and myocardial dysfunction. METHODS A retrospective study was conducted which included children with MIS-C managed at our institution between April 1, 2020, and February 28, 2022. We divided the population into groups depending on severity based on pediatric intensive care unit (PICU) admission. We compared Z-log-NT-proBNP values across these groups and analyzed Z-log-NT-proBNP dynamics during the one-month follow-up. RESULTS We included 17 participants [median age 3 (2-9) years] and seven (41%) required PICU admission. All (100%) of these cases presented very high (Z-log > 4) levels of NT-proBNP at the time of admission compared to only 5 (50%) patients with non-severe MIS-C (P = 0.025). NT-proBNP was significantly correlated with high-sensitive Troponin I levels (P = 0.045), Ross modified score (P = 0.003) and left ventricle ejection fraction (P = 0.021). CONCLUSION Raised NT-proBNP, specifically very high values (Z-log-NT-proBNP > 4) could help in the early identification of MIS-C patients with myocardial dysfunction requiring inotropic support and PICU admission.
PB Baishideng publishing group inc
SN 2307-8960
YR 2022
FD 2022-10-16
LK http://hdl.handle.net/10668/21683
UL http://hdl.handle.net/10668/21683
LA en
DS RISalud
RD Apr 11, 2025