RT Journal Article
T1 Low adherence to the western and high adherence to the mediterranean dietary patterns could prevent colorectal cancer.
A1 Castelló, Adela
A1 Amiano, Pilar
A1 Fernández de Larrea, Nerea
A1 Martín, Vicente
A1 Alonso, Maria Henar
A1 Castaño-Vinyals, Gemma
A1 Pérez-Gómez, Beatriz
A1 Olmedo-Requena, Rocío
A1 Guevara, Marcela
A1 Fernandez-Tardon, Guillermo
A1 Dierssen-Sotos, Trinidad
A1 Llorens-Ivorra, Cristobal
A1 Huerta, Jose María
A1 Capelo, Rocío
A1 Fernández-Villa, Tania
A1 Díez-Villanueva, Anna
A1 Urtiaga, Carmen
A1 Castilla, Jesús
A1 Jiménez-Moleón, Jose Juan
A1 Moreno, Víctor
A1 Dávila-Batista, Verónica
A1 Kogevinas, Manolis
A1 Aragonés, Nuria
A1 Pollán, Marina
A1 MCC-Spain researchers, 
K1 Colonic neoplasms
K1 Diet
K1 Diet, Mediterranean
K1 Diet, Western
K1 Dietary patterns
K1 Prevention and control
K1 Principal component analysis
K1 Rectal neoplasms
AB To assess if the associations found between three previously identified dietary patterns with breast, prostate and gastric cancer are also observed for colorectal cancer (CRC). MCC-Spain is a multicase-control study that collected information of 1629 incident cases of CRC and 3509 population-based controls from 11 Spanish provinces. Western, Prudent and Mediterranean data-driven dietary patterns-derived in another Spanish case-control study-were reconstructed in MCC-Spain. Their association with CRC was assessed using mixed multivariable logistic regression models considering a possible interaction with sex. Risk by tumor site (proximal colon, distal colon, and rectum) was evaluated using multinomial regression models. While no effect of the Prudent pattern on CRC risk was observed, a high adherence to the Western dietary pattern was associated with increased CRC risk for both males [ORfourth(Q4) vs. first(Q1)quartile (95% CI): 1.45 (1.11;1.91)] and females [ORQ4 vs. Q1 (95% CI): 1.50 (1.07;2.09)] but seem to be confined to distal colon [ORfourth(Q4) vs. first(Q1)quartile (95% CI): 2.02 (1.44;2.84)] and rectal [ORQ4 vs. Q1 (95% CI): 1.46 (1.05;2.01)] tumors. The protective effect of the Mediterranean dietary pattern against CRC was observed for both sexes [males: ORQ4 vs. Q1 (95% CI): 0.71 (0.55;0.92); females: ORQ4 vs. Q1 (95% CI): 0.56 (0.40;0.77)] and for all cancer sites: proximal colon [ORQ4 vs. Q1 (95% CI): 0.70 (0.51;0.97)], distal colon [ORQ4 vs. Q1 (95% CI): 0.65 (0.48;0.89)], and rectum (ORQ4 vs. Q1 (95% CI): 0.60 (0.45;0.81)]. Our results are consistent with most of the associations previously found between these patterns and breast, prostate and gastric cancer risk and indicate that consuming whole fruits, vegetables, legumes, olive oil, nuts, and fish and avoiding red and processed meat, refined grains, sweets, caloric drinks, juices, convenience food, and sauces might reduce CRC risk.
YR 2018
FD 2018-03-26
LK http://hdl.handle.net/10668/12279
UL http://hdl.handle.net/10668/12279
LA en
DS RISalud
RD Apr 11, 2025