RT Journal Article
T1 Characteristics and Outcomes of Staphylococcus aureus Bloodstream Infection Originating From the Urinary Tract: A Multicenter Cohort Study
A1 Grillo, Sara
A1 Cuervo, Guillermo
A1 Carratalà, Jordi
A1 Grau, Immaculada
A1 Llaberia, Mariona
A1 Aguado, José María
A1 Lopez-Cortés, Luis Eduardo
A1 Lalueza, Antonio
A1 Sanjuan, Rafael
A1 Sanchez-Batanero, Ana
A1 Ardanuy, Carmen
A1 García-Somoza, Dolors
A1 Tebé, Cristian
A1 Pujol, Miquel
K1 Bacteremia
K1 Staphylococcus aureus
K1 Urinary devices
K1 Urinary tract infection
K1 Staphylococcal Infections
K1 Bacteriemia
K1 Infecciones urinarias
K1 Infecciones estafilocócicas
AB BackgroundStaphylococcus aureus bloodstream infection (SABSI) arising from a urinary tract source (UTS) is poorly understood.MethodsWe conducted a retrospective analysis in 3 major teaching hospitals in Spain of prospectively collected data of hospitalized patients with SABSI. SABSI-UTS was diagnosed in patients with urinary tract symptoms and/or signs, no evidence of an extra-urinary source of infection, and a urinary S. aureus count of ≥105 cfu/mL. Susceptibility of S. aureus strains and patient mortality were compared between SABSI from UTS (SABSI-UTS) and other sources (SABSI-other).ResultsOf 4181 episodes of SABSI, we identified 132 (3.16%) cases of SABSI-UTS that occurred predominantly in patients who were male, had high Charlson comorbidity scores, were dependent for daily life activities, and who had undergone urinary catheterization and/or urinary manipulation before the infection. SABSI-UTS was more often caused by MRSA strains compared with SABSI-other (40.9% vs 17.5%; P < .001). Patients with SABSI-UTS caused by MRSA more often received inadequate empirical treatment compared with those caused by susceptible strains (59.7% vs 23.1%; P < .001). The 30-day case fatality rate was lower in patients with SABSI-UTS than in those with SABSI-other (14.4% vs 23.8%; P = .02). Factors independently associated with mortality were dependence for daily activities (aOR, 3.877; 95% CI, 1.08–13.8; P = .037) and persistent bacteremia (aOR, 7.88; 95% CI, 1.57–39.46; P = .012).ConclusionsSABSI-UTS occurs predominantly in patients with severe underlying conditions and in those who have undergone urinary tract manipulation. Moreover, it is frequently due to MRSA strains and causes significant mortality.
PB Oxford University Press, on behalf of Infectious Diseases Society of America.
YR 2020
FD 2020-06-06
LK http://hdl.handle.net/10668/3554
UL http://hdl.handle.net/10668/3554
LA en
NO Grillo S, Cuervo G, Carratalà J, Grau I, Llaberia M, Aguado JM, Lopez-Cortés LE, Lalueza A, Sanjuan R, Sanchez-Batanero A, Ardanuy C, García-Somoza D, Tebé C, Pujol M. Characteristics and Outcomes of Staphylococcus aureus Bloodstream Infection Originating From the Urinary Tract: A Multicenter Cohort Study. Open Forum Infect Dis. 2020 Jun 6;7(7):ofaa216
DS RISalud
RD Apr 7, 2025