RT Journal Article
T1 Circulating miR-320a as a Predictive Biomarker for Left Ventricular Remodelling in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention
A1 Galeano-Otero, Isabel
A1 Del Toro, Raquel
A1 Guisado, Agustín
A1 Díaz, Ignacio
A1 Mayoral-González, Isabel
A1 Guerrero-Márquez, Francisco
A1 Gutiérrez-Carretero, Encarnación
A1 Casquero-Domínguez, Sara
A1 Díaz-de la Llera, Luis
A1 Barón-Esquivias, Gonzalo
A1 Jiménez-Navarro, Manuel
A1 Smani, Tarik
A1 Ordóñez-Fernández, Antonio
K1 STEMI
K1 PPCI
K1 Left ventricular adverse remodelling
K1 Circulating miRNAs
K1 Myocardium
K1 Heart failure
K1 Perfusion
K1 Infarto del miocardio con elevación del ST
K1 Miocardio
K1 Insuficiencia cardíaca
AB Restoration of epicardial coronary blood flow, achieved by early reperfusion with primary percutaneous coronary intervention (PPCI), is the guideline recommended to treat patients with ST-segment-elevation myocardial infarction (STEMI). However, despite successful blood restoration, increasing numbers of patients develop left ventricular adverse remodelling (LVAR) and heart failure. Therefore, reliable prognostic biomarkers for LVAR in STEMI are urgently needed. Our aim was to investigate the role of circulating microRNAs (miRNAs) and their association with LVAR in STEMI patients following the PPCI procedure. We analysed the expression of circulating miRNAs in blood samples of 56 patients collected at admission and after revascularization (at 3, 6, 12 and 24 h). The associations between miRNAs and left ventricular end diastolic volumes at 6 months were estimated to detect LVAR. miRNAs were also analysed in samples isolated from peripheral blood mononuclear cells (PBMCs) and human myocardium of failing hearts. Kinetic analysis of miRNAs showed a fast time-dependent increase in miR-133a, miR-133b, miR-193b, miR-499, and miR-320a in STEMI patients compared to controls. Moreover, the expression of miR-29a, miR-29b, miR-324, miR-208, miR-423, miR-522, and miR-545 was differentially expressed even before PPCI in STEMI. Furthermore, the increase in circulating miR-320a and the decrease in its expression in PBMCs were significantly associated with LVAR and correlated with the expression of miR-320a in human failing myocardium from ischaemic origin. In conclusion, we determined the time course expression of new circulating miRNAs in patients with STEMI treated with PPCI and we showed that miR-320a was positively associated with LVAR.
PB MDPI
YR 2020
FD 2020-04-08
LK http://hdl.handle.net/10668/3946
UL http://hdl.handle.net/10668/3946
LA en
NO Galeano-Otero I, Del Toro R, Guisado A, Díaz I, Mayoral-González I, Guerrero-Márquez F, et al. Circulating miR-320a as a Predictive Biomarker for Left Ventricular Remodelling in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention. J Clin Med. 2020 Apr 8;9(4):1051
DS RISalud
RD Sep 22, 2025