RT Journal Article
T1 Prospective randomised multicentre study to demonstrate the benefits of haemodialysis without acetate (with citrate): ABC-treat Study. Acute effect of citrate.
T2 Estudio prospectivo aleatorizado multicéntrico para demostrar los beneficios de la hemodiálisis sin acetato (con citrato): Estudio ABC-treat. Efecto agudo del citrato.
A1 de Sequera Ortiz, Patricia
A1 Pérez García, Rafael
A1 Molina Nuñez, Manuel
A1 Muñoz González, Rosa Inés
A1 Álvarez Fernández, Gracia
A1 Mérida Herrero, Eva
A1 Camba Caride, María Jesús
A1 Blázquez Collado, Luís Alberto
A1 Alcaide Lara, M Paz
A1 Echarri Carrillo, Rocío
A1 en representación del grupo del estudio ABC-treat, 
A1 Grupo del estudio ABC-treat, 
K1 Acetate
K1 Acetato
K1 Arterial hypotension
K1 Bicarbonate
K1 Bicarbonato
K1 Calcio
K1 Calcium
K1 Citrate
K1 Citrato
K1 Hemodialysis
K1 Hemodiálisis
K1 Hipotensión arterial
K1 Magnesio
K1 Magnesium
AB Dialysis fluid (DF), an essential element in hemodialysis (HD), is manufactured in situ by mixing three components: treated water, bicarbonate concentrate and acid concentrate. To avoid the precipitation of calcium and magnesium carbonate that is produced in DF by the addition of bicarbonate, it is necessary to add an acid. There are 2 acid concentrates that contain acetate (ADF) or citrate (CDF) as a stabilizer. To compare the acute effect of HD with CDF vs. ADF on the metabolism of calcium, phosphorus and magnesium, acid base balance, coagulation, inflammation and hemodynamic stability. Prospective, multicenter, randomized and crossed study, of 32 weeks duration, in patients in three-week HD, AK-200-Ultra-S or Artis monitor, 16 weeks with ADF SoftPac®, prepared with 3mmol/L of acetate, and 16 weeks with CDF SelectBag Citrate®, with 1mmol/L of citrate. Patients older than 18 years were included in HD for a minimum of 3 months by arteriovenous fistula. Epidemiological, dialysis, pre and postdialysis biochemistry, episodes of arterial hypotension, and coagulation scores were collected monthly during the 8 months of the study. Pre and post-dialysis analysis were extracted: venous blood gas, calcium (Ca), ionic calcium (Cai), phosphorus (P), magnesium (Mg) and parathyroid hormone (PTH) among others. ClinicalTrials.gov NCT03319680. We included 56 patients, 47 (84%) men and 9 (16%) women, mean age: 65.3 (16.4) years, technique HD/HDF: 20 (35.7%)/36 (64.3%). We found differences (p Dialysis with citrate acutely produces less postdialysis alkalemia and significantly modifies Ca, Mg and PTH. CDF has a positive impact on hemodynamic tolerance.
YR 2019
FD 2019-01-24
LK http://hdl.handle.net/10668/13467
UL http://hdl.handle.net/10668/13467
LA en
LA es
DS RISalud
RD Apr 7, 2025