RT Journal Article
T1 Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.
A1 Axfors, Cathrine
A1 Janiaud, Perrine
A1 Schmitt, Andreas M
A1 Van't Hooft, Janneke
A1 Smith, Emily R
A1 Haber, Noah A
A1 Abayomi, Akin
A1 Abduljalil, Manal
A1 Abdulrahman, Abdulkarim
A1 Acosta-Ampudia, Yeny
A1 Aguilar-Guisado, Manuela
A1 Al-Beidh, Farah
A1 Alejandria, Marissa M
A1 Alfonso, Rachelle N
A1 Ali, Mohammad
A1 AlQahtani, Manaf
A1 AlZamrooni, Alaa
A1 Anaya, Juan-Manuel
A1 Ang, Mark Angelo C
A1 Aomar, Ismael F
A1 Argumanis, Luis E
A1 Averyanov, Alexander
A1 Baklaushev, Vladimir P
A1 Balionis, Olga
A1 Benfield, Thomas
A1 Berry, Scott
A1 Birocco, Nadia
A1 Bonifacio, Lynn B
A1 Bowen, Asha C
A1 Bown, Abbie
A1 Cabello-Gutierrez, Carlos
A1 Camacho, Bernardo
A1 Camacho-Ortiz, Adrian
A1 Campbell-Lee, Sally
A1 Cao, Damon H
A1 Cardesa, Ana
A1 Carnate, Jose M
A1 Castillo, German Jr J
A1 Cavallo, Rossana
A1 Chowdhury, Fazle R
A1 Chowdhury, Forhad U H
A1 Ciccone, Giovannino
A1 Cingolani, Antonella
A1 Climacosa, Fresthel Monica M
A1 Compernolle, Veerle
A1 Cortez, Carlo Francisco N
A1 Costa Neto, Abel
A1 D'Antico, Sergio
A1 Daly, James
A1 Danielle, Franca
A1 Davis, Joshua S
A1 De Rosa, Francesco Giuseppe
A1 Denholm, Justin T
A1 Denkinger, Claudia M
A1 Desmecht, Daniel
A1 Diaz-Coronado, Juan C
A1 Diaz Ponce-Medrano, Juan A
A1 Donneau, Anne-Françoise
A1 Dumagay, Teresita E
A1 Dunachie, Susanna
A1 Dungog, Cecile C
A1 Erinoso, Olufemi
A1 Escasa, Ivy Mae S
A1 Estcourt, Lise J
A1 Evans, Amy
A1 Evasan, Agnes L M
A1 Fareli, Christian J
A1 Fernandez-Sanchez, Veronica
A1 Galassi, Claudia
A1 Gallo, Juan E
A1 Garcia, Patricia J
A1 Garcia, Patricia L
A1 Garcia, Jesus A
A1 Garigliany, Mutien
A1 Garza-Gonzalez, Elvira
A1 Gauiran, Deonne Thaddeus V
A1 Gaviria García, Paula A
A1 Giron-Gonzalez, Jose-Antonio
A1 Gomez-Almaguer, David
A1 Gordon, Anthony C
A1 Gothot, Andre
A1 Grass Guaqueta, Jeser Santiago
A1 Green, Cameron
A1 Grimaldi, David
A1 Hammond, Naomi E
A1 Harvala, Heli
A1 Heralde, Francisco M
A1 Herrick, Jesica
A1 Higgins, Alisa M
A1 Hills, Thomas E
A1 Hines, Jennifer
A1 Holm, Karin
A1 Hoque, Ashraful
A1 Hoste, Eric
A1 Ignacio, Jose M
A1 Ivanov, Alexander V
A1 Janssen, Maike
A1 Jennings, Jeffrey H
A1 Jha, Vivekanand
A1 King, Ruby Anne N
A1 Kjeldsen-Kragh, Jens
A1 Klenerman, Paul
A1 Kotecha, Aditya
A1 Krapp, Fiorella
A1 Labanca, Luciana
A1 Laing, Emma
A1 Landin-Olsson, Mona
A1 Laterre, Pierre-François
A1 Lim, Lyn-Li
A1 Lim, Jodor
A1 Ljungquist, Oskar
A1 Llaca-Díaz, Jorge M
A1 Lopez-Robles, Concepcion
A1 Lopez-Cardenas, Salvador
A1 Lopez-Plaza, Ileana
A1 Lucero, Josephine Anne C
A1 Lundgren, Maria
A1 Macias, Juan
A1 Maganito, Sandy C
A1 Malundo, Anna Flor G
A1 Manrique, Ruben D
A1 Manzini, Paola M
A1 Marcos, Miguel
A1 Marquez, Ignacio
A1 Martinez-Marcos, Francisco Javier
A1 Mata, Ana M
A1 McArthur, Colin J
A1 McQuilten, Zoe K
A1 McVerry, Bryan J
A1 Menon, David K
A1 Meyfroidt, Geert
A1 Mirasol, Ma Angelina L
A1 Misset, Benoît
A1 Molton, James S
A1 Mondragon, Alric V
A1 Monsalve, Diana M
A1 Moradi Choghakabodi, Parastoo
A1 Morpeth, Susan C
A1 Mouncey, Paul R
A1 Moutschen, Michel
A1 Müller-Tidow, Carsten
A1 Murphy, Erin
A1 Najdovski, Tome
A1 Nichol, Alistair D
A1 Nielsen, Henrik
A1 Novak, Richard M
A1 O'Sullivan, Matthew V N
A1 Olalla, Julian
A1 Osibogun, Akin
A1 Osikomaiya, Bodunrin
A1 Oyonarte, Salvador
A1 Pardo-Oviedo, Juan M
A1 Patel, Mahesh C
A1 Paterson, David L
A1 Peña-Perez, Carlos A
A1 Perez-Calatayud, Angel A
A1 Perez-Alba, Eduardo
A1 Perkina, Anastasia
A1 Perry, Naomi
A1 Pouladzadeh, Mandana
A1 Poyato, Inmaculada
A1 Price, David J
A1 Quero, Anne Kristine H
A1 Rahman, Md M
A1 Rahman, Md S
A1 Ramesh, Mayur
A1 Ramirez-Santana, Carolina
A1 Rasmussen, Magnus
A1 Rees, Megan A
A1 Rego, Eduardo
A1 Roberts, Jason A
A1 Roberts, David J
A1 Rodriguez, Yhojan
A1 Rodriguez-Baño, Jesus
A1 Rogers, Benjamin A
A1 Rojas, Manuel
A1 Romero, Alberto
A1 Rowan, Kathryn M
A1 Saccona, Fabio
A1 Safdarian, Mehdi
A1 Santos, Maria Clariza M
A1 Sasadeusz, Joe
A1 Scozzari, Gitana
A1 Shankar-Hari, Manu
A1 Sharma, Gorav
A1 Snelling, Thomas
A1 Soto, Alonso
A1 Tagayuna, Pedrito Y
A1 Tang, Amy
A1 Tatem, Geneva
A1 Teofili, Luciana
A1 Tong, Steven Y C
A1 Turgeon, Alexis F
A1 Veloso, Januario D
A1 Venkatesh, Balasubramanian
A1 Ventura-Enriquez, Yanet
A1 Webb, Steve A
A1 Wiese, Lothar
A1 Wikén, Christian
A1 Wood, Erica M
A1 Yusubalieva, Gaukhar M
A1 Zacharowski, Kai
A1 Zarychanski, Ryan
A1 Khanna, Nina
A1 Moher, David
A1 Goodman, Steven N
A1 Ioannidis, John P A
A1 Hemkens, Lars G
K1 COVID-19
K1 Convalescent plasma
K1 Meta-analysis
K1 SARS-CoV-2
K1 Red Andaluza de Diseño y Traslacion de Terapias Avanzadas,
K1 Centro Transfusional Tejidos y Celulas de Sevilla, Sevilla
AB Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ). In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung-Knapp-Sidik-Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis. Convalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care.
PB BioMed Central Ltd.
YR 2021
FD 2021-11-20
LK https://hdl.handle.net/10668/24965
UL https://hdl.handle.net/10668/24965
LA en
NO Axfors C, Janiaud P, Schmitt AM, Van't Hooft J, Smith ER, Haber NA, et al. Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials. BMC Infect Dis. 2021 Nov 20;21(1):1170
DS RISalud
RD Apr 11, 2025