RT Journal Article
T1 Assessment of Brain Injury and Brain Volumes after Posthemorrhagic Ventricular Dilatation: A Nested Substudy of the Randomized Controlled ELVIS Trial.
A1 Cizmeci, Mehmet N
A1 Khalili, Nadieh
A1 Claessens, Nathalie H P
A1 Groenendaal, Floris
A1 Liem, Kian D
A1 Heep, Axel
A1 Benavente-Fernández, Isabel
A1 van Straaten, Henrica L M
A1 van Wezel-Meijler, Gerda
A1 Steggerda, Sylke J
A1 Dudink, Jeroen
A1 Išgum, Ivana
A1 Whitelaw, Andrew
A1 Benders, Manon J N L
A1 de Vries, Linda S
A1 ELVIS study group, 
K1 MRI
K1 newborn
K1 posthemorrhagic ventricular dilatation
AB To compare the effect of early and late intervention for posthemorrhagic ventricular dilatation on additional brain injury and ventricular volume using term-equivalent age-MRI. In the Early vs Late Ventricular Intervention Study (ELVIS) trial, 126 preterm infants ≤34 weeks of gestation with posthemorrhagic ventricular dilatation were randomized to low-threshold (ventricular index >p97 and anterior horn width >6 mm) or high-threshold (ventricular index >p97 + 4 mm and anterior horn width >10 mm) groups. In 88 of those (80%) with a term-equivalent age-MRI, the Kidokoro Global Brain Abnormality Score and the frontal and occipital horn ratio were measured. Automatic segmentation was used for volumetric analysis. The total Kidokoro score of the infants in the low-threshold group (n = 44) was lower than in the high-threshold group (n = 44; median, 8 [IQR, 5-12] vs median 12 [IQR, 9-17], respectively; P  More brain injury and larger ventricular volumes were demonstrated in the high vs the low-threshold group. These results support the positive effects of early intervention for posthemorrhagic ventricular dilatation. ISRCTN43171322.
YR 2019
FD 2019-03-14
LK http://hdl.handle.net/10668/13715
UL http://hdl.handle.net/10668/13715
LA en
DS RISalud
RD Apr 5, 2025