%0 Journal Article
%A Fernández-Pérez, G C
%A Oñate Miranda, M
%A Fernández-Rodríguez, P
%A Velasco Casares, M
%A Corral de la Calle, M
%A Franco López, Á
%A Díez Blanco, M
%A Cuchat, J M Oñate
%T SARS-CoV-2: what it is, how it acts, and how it manifests in imaging studies.
%D 2020
%U http://hdl.handle.net/10668/16781
%X COVID-19 is a disease with many clinical, biochemical, and radiological signs that has a predilection for the lungs, probably because of the high number of ACE-2 receptors in this organ. The infection of cells activates proinflammatory substances, causing diffuse alveolar damage, which is the histopathological basis of ARDS. The exudative phase would manifest as ground-glass opacities and consolidation, and the proliferative phase would manifest as a tendency toward a more linear morphology. Both CT and PET/CT findings support the inflammatory character of the lung lesions in the initial phase of the disease and in patients with mild-moderate disease. Severe cases have pulmonary hypoperfusion that is likely due to abnormal alveolar ventilation and perfusion. On the other hand, a prothrombotic state increases the risk of thromboembolic disease through the activation of coagulation and platelet pathways with the production of fibrin degradation products (D-dimer) and consumption of platelets.
%K COVID-19
%K PET/TC
%K Percusión pulmonar PBV
%K SARS-2
%K SARS-CoV-2
%K TC alta resolución
%K TC doble energía
%K dual-energy CT
%K high-resolution CT
%K lung perfusion blood volume
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