RT Journal Article
T1 Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults-A randomized controlled double-blinded crossover study.
A1 Müller, Patrick
A1 Vellage, Anne-Katrin
A1 Schmicker, Marlen
A1 Menze, Inga
A1 Grothe, Michel J
A1 Teipel, Stefan J
A1 Müller, Notger G
K1 Alzheimer's disease
K1 basal forebrain
K1 galantamine
K1 magnetic resonance imaging
K1 personalized medicine
AB Cholinesterase inhibitors can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s disease (AD). However, not everyone benefits from this treatment (non-responders). Current studies show clinical meaningful improvements only in one third of AD patients treated with cholinesterase inhibitors. Here we investigate structural magnetic resonance imaging of the basal forebrain cholinergic system volume (BFvol) as a potential predictor of cognitive response to a single dose of galantamine in healthy adults (n = 18; 59 to 75 years). We observed that the cognitive response to galantamine, more specifically the attention-dependent filtering performance in a delayed match-to-sample working memory task, correlated with BFvol: Only participants with high BFvol showed a significant positive effect of galantamine on the ability to filter out distracting information during the working memory encoding process. Future studies need to assess whether BFvol may serve as a predictor of the galantamine response in AD patients, too.
PB John Wiley & Sons, Inc.
YR 2021
FD 2021-04-02
LK https://hdl.handle.net/10668/27389
UL https://hdl.handle.net/10668/27389
LA en
NO Müller P, Vellage AK, Schmicker M, Menze I, Grothe MJ, Teipel SJ, et al. Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults-A randomized controlled double-blinded crossover study. Alzheimers Dement (N Y). 2021 Apr 5;7(1):e12153
DS RISalud
RD Apr 19, 2025