RT Journal Article
T1 Cutaneous and Vascular Deposits of 18F-NaF by PET/CT in the Follow-Up of Patients with Pseudoxanthoma Elasticum
A1 Lillo, Eugenia
A1 Gutierrez-Cardo, Antonio
A1 Murcia-Casas, Belen
A1 Carrillo-Linares, Juan Luis
A1 Garcia-Argüello, Francisco
A1 Chicharo-de-Freitas, Reinaldo
A1 Baquero-Aranda, Isabel
A1 Valdivielso, Pedro
A1 Garcia-Fernandez, Maria
A1 Sanchez-Chaparro, Miguel Angel
K1 Pseudoxanthoma elasticum
K1 Inorganic pyrophosphate
K1 Microcalcification
K1 18F-NaF
K1 PET/CT
AB Active microcalcification of elastic fibers is a hallmark of pseudoxanthoma elasticum and it can be measured with the assessment of deposition of 18F-NaF using a PET/CT scan at the skin and vascular levels. It is not known whether this deposition changes over time in absence of specific therapy. We repeated in two years a PET/CT scan using 18F-NaF as a radiopharmaceutical in patients with the disease and compared the deposition at skin and vessel. Furthermore, calcium score values at the vessel wall were also assessed. Main results indicate in the vessel walls that calcification progressed in each patient; by contrast, the active microcalcification, measured and target-to-background ratio showed reduced active deposition. By contrast, at skin levels (neck and axillae) the uptake of the pharmaceutical remains unchanged. In conclusion, because calcification in the arterial wall is not specific for pseudoxanthoma elasticum condition, the measurement of the deposition of 18F-NaF in the neck might be potentially used as a surrogate marker in future trials for the disease.
PB MDPI
YR 2021
FD 2021-06-11
LK http://hdl.handle.net/10668/4491
UL http://hdl.handle.net/10668/4491
LA en
NO Lillo E, Gutierrez-Cardo A, Murcia-Casas B, Carrillo-Linares JL, Garcia-Argüello F, Chicharo de Freitas R, et al. Cutaneous and Vascular Deposits of 18F-NaF by PET/CT in the Follow-Up of Patients with Pseudoxanthoma Elasticum. J Clin Med. 2021 Jun 11;10(12):2588
NO This research was funded by Grant number PI16/01579 from Fondo de Investigaciones Sanitarias (FIS), ISCIII, European Regional Development Fund (FEDER, “A Way to Make Europe”) and funds from the CTS-159 Group, PAIDI.
DS RISalud
RD Apr 5, 2025