RT Journal Article
T1 Reallocation of Olfactory Cajal-Retzius Cells Shapes Neocortex Architecture.
A1 de Frutos, Cristina A
A1 Bouvier, Guy
A1 Arai, Yoko
A1 Thion, Morgane S
A1 Lokmane, Ludmilla
A1 Keita, Maryama
A1 Garcia-Dominguez, Mario
A1 Charnay, Patrick
A1 Hirata, Tatsumi
A1 Riethmacher, Dieter
A1 Grove, Elizabeth A
A1 Tissir, Fadel
A1 Casado, Mariano
A1 Pierani, Alessandra
A1 Garel, Sonia
K1 Cajal-Retzius cells
K1 E/I ratio
K1 NMDA receptors
K1 interneurons
K1 layer 1
K1 marginal zone
K1 migration
K1 neocortex
K1 olfactory cortex
AB The neocortex undergoes extensive developmental growth, but how its architecture adapts to expansion remains largely unknown. Here, we investigated how early born Cajal-Retzius (CR) neurons, which regulate the assembly of cortical circuits, maintain a dense superficial distribution in the growing neocortex. We found that CR cell density is sustained by an activity-dependent importation of olfactory CR cells, which migrate into the neocortex after they have acted as axonal guidepost cells in the olfactory system. Furthermore, using mouse genetics, we showed that CR cell density severely affects the architecture of layer 1, a key site of input integration for neocortical networks, leading to an excitation/inhibition ratio imbalance. Our study reveals that neurons reenter migration several days after their initial positioning, thereby performing sequential developmental roles in olfactory cortex and neocortex. This atypical process is essential to regulate CR cell density during growth, which in turn ensures the correct wiring of neocortical circuitry. VIDEO ABSTRACT.
YR 2016
FD 2016-09-29
LK http://hdl.handle.net/10668/10497
UL http://hdl.handle.net/10668/10497
LA en
DS RISalud
RD Apr 5, 2025