RT Journal Article
T1 Incidence, Clinical Characteristics, Risk Factors and Outcomes of Acute Coronary Syndrome in Patients With COVID-19: Results of the UMC-19-S1010.
A1 Alquézar-Arbé, Aitor
A1 Miró, Òscar
A1 Castillo, Juan González Del
A1 Jiménez, Sònia
A1 Llorens, Pere
A1 Martín, Alfonso
A1 Martín-Sánchez, Francisco Javier
A1 García-Lamberechts, Eric Jorge
A1 Piñera, Pascual
A1 Jacob, Javier
A1 Porrino, Juan Miguel Marín
A1 Jiménez, Blas
A1 Río, Rigoberto Del
A1 García, Carles Pérez
A1 Aznar, José Vicente Brasó
A1 Ponce, María Carmen
A1 Fernández, Elena Díaz
A1 Tost, Josep
A1 Mojarro, Enrique Martín
A1 García, Arturo Huerta
A1 Quirós, Alejandro Martín
A1 Noceda, José
A1 Cano, María José Cano
A1 Almela, Amparo Fernández de Simón
A1 Bayarri, María José Fortuny
A1 Tejera, Matilde González
A1 Rodriguez, Alberto Domínguez
A1 Burillo-Putze, Guillermo
A1 Spanish Investigators on Emergency Situations TeAm (SIESTA) Network, 
K1 COVID-19
K1 SARS-Cov-2
K1 acute coronary syndrome
K1 clinical characteristics
K1 incidence
K1 outcome
K1 risk factors
AB There is a lack of knowledge about the real incidence of acute coronary syndrome (ACS) in patients with COVID-19, their clinical characteristics, and their prognoses. We investigated the incidence, clinical characteristics, risk factors, and outcomes of ACS in patients with COVID-19 in the emergency department. We retrospectively reviewed all COVID-19 patients diagnosed with ACS in 62 Spanish emergency departments between March and April 2020 (the first wave of COVID-19). We formed 2 control groups: COVID-19 patients without ACS (control A) and non-COVID-19 patients with ACS (control B). Unadjusted comparisons between cases and control subjects were performed regarding 58 characteristics and outcomes. We identified 110 patients with ACS in 74,814 patients with COVID-19 attending the ED (1.48% [95% confidence interval {CI} 1.21-1.78%]). This incidence was lower than that observed in non-COVID-19 patients (3.64% [95% CI 3.54-3.74%]; odds ratio [OR] 0.40 [95% CI 0.33-0.49]). The clinical characteristics of patients with COVID-19 associated with a higher risk of presenting ACS were: previous coronary artery disease, age ≥60 years, hypertension, chest pain, raised troponin, and hypoxemia. The need for hospitalization and admission to intensive care and in-hospital mortality were higher in cases than in control group A (adjusted OR [aOR] 6.36 [95% CI 1.84-22.1], aOR 4.63 [95% CI 1.88-11.4], and aOR 2.46 [95% CI 1.15-5.25]). When comparing cases with control group B, the aOR of admission to intensive care was 0.41 (95% CI 0.21-0.80), while the aOR for in-hospital mortality was 5.94 (95% CI 2.84-12.4). The incidence of ACS in patients with COVID-19 attending the emergency department was low, around 1.48%, but could be increased in some circumstances. Patients with COVID-19 with ACS had a worse prognosis than control subjects with higher in-hospital mortality.
YR 2021
FD 2021-11-03
LK http://hdl.handle.net/10668/22302
UL http://hdl.handle.net/10668/22302
LA en
DS RISalud
RD Apr 11, 2025