RT Journal Article
T1 Association Between Transcatheter Aortic Valve Replacement and Subsequent Infective Endocarditis and In-Hospital Death.
A1 Regueiro, Ander
A1 Linke, Axel
A1 Latib, Azeem
A1 Ihlemann, Nikolaj
A1 Urena, Marina
A1 Walther, Thomas
A1 Husser, Oliver
A1 Herrmann, Howard C
A1 Nombela-Franco, Luis
A1 Cheema, Asim N
A1 Le Breton, Hervé
A1 Stortecky, Stefan
A1 Kapadia, Samir
A1 Bartorelli, Antonio L
A1 Sinning, Jan Malte
A1 Amat-Santos, Ignacio
A1 Munoz-Garcia, Antonio
A1 Lerakis, Stamatios
A1 Gutiérrez-Ibanes, Enrique
A1 Abdel-Wahab, Mohamed
A1 Tchetche, Didier
A1 Testa, Luca
A1 Eltchaninoff, Helene
A1 Livi, Ugolino
A1 Castillo, Juan Carlos
A1 Jilaihawi, Hasan
A1 Webb, John G
A1 Barbanti, Marco
A1 Kodali, Susheel
A1 de Brito, Fabio S
A1 Ribeiro, Henrique B
A1 Miceli, Antonio
A1 Fiorina, Claudia
A1 Dato, Guglielmo Mario Actis
A1 Rosato, Francesco
A1 Serra, Vicenç
A1 Masson, Jean-Bernard
A1 Wijeysundera, Harindra C
A1 Mangione, Jose A
A1 Ferreira, Maria-Cristina
A1 Lima, Valter C
A1 Carvalho, Luiz A
A1 Abizaid, Alexandre
A1 Marino, Marcos A
A1 Esteves, Vinicius
A1 Andrea, Julio C M
A1 Giannini, Francesco
A1 Messika-Zeitoun, David
A1 Himbert, Dominique
A1 Kim, Won-Keun
A1 Pellegrini, Costanza
A1 Auffret, Vincent
A1 Nietlispach, Fabian
A1 Pilgrim, Thomas
A1 Durand, Eric
A1 Lisko, John
A1 Makkar, Raj R
A1 Lemos, Pedro A
A1 Leon, Martin B
A1 Puri, Rishi
A1 San Roman, Alberto
A1 Vahanian, Alec
A1 Søndergaard, Lars
A1 Mangner, Norman
A1 Rodés-Cabau, Josep
AB Limited data exist on clinical characteristics and outcomes of patients who had infective endocarditis after undergoing transcatheter aortic valve replacement (TAVR). To determine the associated factors, clinical characteristics, and outcomes of patients who had infective endocarditis after TAVR. The Infectious Endocarditis after TAVR International Registry included patients with definite infective endocarditis after TAVR from 47 centers from Europe, North America, and South America between June 2005 and October 2015. Transcatheter aortic valve replacement for incidence of infective endocarditis and infective endocarditis for in-hospital mortality. Infective endocarditis and in-hospital mortality after infective endocarditis. A total of 250 cases of infective endocarditis occurred in 20 006 patients after TAVR (incidence, 1.1% per person-year; 95% CI, 1.1%-1.4%; median age, 80 years; 64% men). Median time from TAVR to infective endocarditis was 5.3 months (interquartile range [IQR], 1.5-13.4 months). The characteristics associated with higher risk of progressing to infective endocarditis after TAVR was younger age (78.9 years vs 81.8 years; hazard ratio [HR], 0.97 per year; 95% CI, 0.94-0.99), male sex (62.0% vs 49.7%; HR, 1.69; 95% CI, 1.13-2.52), diabetes mellitus (41.7% vs 30.0%; HR, 1.52; 95% CI, 1.02-2.29), and moderate to severe aortic regurgitation (22.4% vs 14.7%; HR, 2.05; 95% CI, 1.28-3.28). Health care-associated infective endocarditis was present in 52.8% (95% CI, 46.6%-59.0%) of patients. Enterococci species and Staphylococcus aureus were the most frequently isolated microorganisms (24.6%; 95% CI, 19.1%-30.1% and 23.3%; 95% CI, 17.9%-28.7%, respectively). The in-hospital mortality rate was 36% (95% CI, 30.0%-41.9%; 90 deaths; 160 survivors), and surgery was performed in 14.8% (95% CI, 10.4%-19.2%) of patients during the infective endocarditis episode. In-hospital mortality was associated with a higher logistic EuroSCORE (23.1% vs 18.6%; odds ratio [OR], 1.03 per 1% increase; 95% CI, 1.00-1.05), heart failure (59.3% vs 23.7%; OR, 3.36; 95% CI, 1.74-6.45), and acute kidney injury (67.4% vs 31.6%; OR, 2.70; 95% CI, 1.42-5.11). The 2-year mortality rate was 66.7% (95% CI, 59.0%-74.2%; 132 deaths; 115 survivors). Among patients undergoing TAVR, younger age, male sex, history of diabetes mellitus, and moderate to severe residual aortic regurgitation were significantly associated with an increased risk of infective endocarditis. Patients who developed endocarditis had high rates of in-hospital mortality and 2-year mortality.
YR 2016
FD 2016
LK http://hdl.handle.net/10668/10441
UL http://hdl.handle.net/10668/10441
LA en
DS RISalud
RD Apr 11, 2025