RT Journal Article
T1 Omics Approaches in Adipose Tissue and Skeletal Muscle Addressing the Role of Extracellular Matrix in Obesity and Metabolic Dysfunction.
A1 Anguita-Ruiz, Augusto
A1 Bustos-Aibar, Mireia
A1 Plaza-Díaz, Julio
A1 Mendez-Gutierrez, Andrea
A1 Alcalá-Fdez, Jesús
A1 Aguilera, Concepción María
A1 Ruiz-Ojeda, Francisco Javier
K1 adipose tissue
K1 epigenetic
K1 extracellular matrix
K1 genetics
K1 obesity
K1 skeletal muscle
K1 transcriptomic
AB Extracellular matrix (ECM) remodeling plays important roles in both white adipose tissue (WAT) and the skeletal muscle (SM) metabolism. Excessive adipocyte hypertrophy causes fibrosis, inflammation, and metabolic dysfunction in adipose tissue, as well as impaired adipogenesis. Similarly, disturbed ECM remodeling in SM has metabolic consequences such as decreased insulin sensitivity. Most of described ECM molecular alterations have been associated with DNA sequence variation, alterations in gene expression patterns, and epigenetic modifications. Among others, the most important epigenetic mechanism by which cells are able to modulate their gene expression is DNA methylation. Epigenome-Wide Association Studies (EWAS) have become a powerful approach to identify DNA methylation variation associated with biological traits in humans. Likewise, Genome-Wide Association Studies (GWAS) and gene expression microarrays have allowed the study of whole-genome genetics and transcriptomics patterns in obesity and metabolic diseases. The aim of this review is to explore the molecular basis of ECM in WAT and SM remodeling in obesity and the consequences of metabolic complications. For that purpose, we reviewed scientific literature including all omics approaches reporting genetic, epigenetic, and transcriptomic (GWAS, EWAS, and RNA-seq or cDNA arrays) ECM-related alterations in WAT and SM as associated with metabolic dysfunction and obesity.
YR 2021
FD 2021-03-09
LK http://hdl.handle.net/10668/17473
UL http://hdl.handle.net/10668/17473
LA en
DS RISalud
RD May 11, 2025