RT Journal Article
T1 Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study.
A1 Baumeister, Sebastian E
A1 Schlesinger, Sabrina
A1 Aleksandrova, Krasimira
A1 Jochem, Carmen
A1 Jenab, Mazda
A1 Gunter, Marc J
A1 Overvad, Kim
A1 Tjønneland, Anne
A1 Boutron-Ruault, Marie-Christine
A1 Carbonnel, Franck
A1 Fournier, Agnès
A1 Kühn, Tilman
A1 Kaaks, Rudolf
A1 Pischon, Tobias
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Bamia, Christina
A1 La Vecchia, Carlo
A1 Masala, Giovanna
A1 Panico, Salvatore
A1 Fasanelli, Francesca
A1 Tumino, Rosario
A1 Grioni, Sara
A1 Bueno de Mesquita, Bas
A1 Vermeulen, Roel
A1 May, Anne M
A1 Borch, Kristin B
A1 Oyeyemi, Sunday O
A1 Ardanaz, Eva
A1 Rodríguez-Barranco, Miguel
A1 Dolores Chirlaque López, María
A1 Felez-Nobrega, Mireia
A1 Sonestedt, Emily
A1 Ohlsson, Bodil
A1 Hemmingsson, Oskar
A1 Werner, Mårten
A1 Perez-Cornago, Aurora
A1 Ferrari, Pietro
A1 Stepien, Magdalena
A1 Freisling, Heinz
A1 Tsilidis, Konstantinos K
A1 Ward, Heather
A1 Riboli, Elio
A1 Weiderpass, Elisabete
A1 Leitzmann, Michael F
K1 Hepatobiliary cancer
K1 Hepatocellular carcinoma
K1 Liver cancer
K1 Physical activity
AB To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. We examined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC). We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cancers (NGBCs) among 467,336 EPIC participants (median follow-up 14.9 years). We estimated cause-specific hazard ratios (HRs) for total physical activity and vigorous physical activity and performed mediation analysis and secondary analyses to assess robustness to confounding (e.g. due to hepatitis virus infection). In the EPIC cohort, the multivariable-adjusted HR of HCC was 0.55 (95% CI 0.38-0.80) comparing active and inactive individuals. Regarding vigorous physical activity, for those reporting >2 hours/week compared to those with no vigorous activity, the HR for HCC was 0.50 (95% CI 0.33-0.76). Estimates were similar in sensitivity analyses for confounding. Total and vigorous physical activity were unrelated to IHBC and NGBC. In mediation analysis, waist circumference explained about 40% and body mass index 30% of the overall association of total physical activity and HCC. These findings suggest an inverse association between physical activity and risk of HCC, which is potentially mediated by obesity. In a pan-European study of 467,336 men and women, we found that physical activity is associated with a reduced risk of developing liver cancers over the next decade. This risk was independent of other liver cancer risk factors, and did not vary by age, gender, smoking status, body weight, and alcohol consumption.
PB Elsevier
YR 2018
FD 2018-12-22
LK http://hdl.handle.net/10668/13355
UL http://hdl.handle.net/10668/13355
LA en
NO Baumeister SE, Schlesinger S, Aleksandrova K, Jochem C, Jenab M, Gunter MJ, et al. Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study. J Hepatol. 2019 May;70(5):885-892.
DS RISalud
RD Apr 18, 2025