%0 Journal Article
%A Rodriguez, Marta
%A Alonso-Alonso, Ruth
%A Tomas-Roca, Laura
%A Rodriguez-Pinilla, Socorro M.
%A Manso-Alonso, Rebeca
%A Cereceda, Laura
%A Borregon, Jennifer
%A Villaescusa, Teresa
%A Cordoba, Raul
%A Sanchez-Beato, Margarita
%A Fernandez-Miranda, Ismael
%A Betancor, Isabel
%A Barcena, Carmen
%A Garcia, Juan F.
%A Mollejo, Manuela
%A Garcia-Cosio, Monica
%A Martin-Acosta, Paloma
%A Climent, Fina
%A Caballero, Dolores
%A de la Fuente, Lorena
%A Minguez, Pablo
%A Kessler, Linda
%A Scholz, Catherine
%A Gualberto, Antonio
%A Mondejar, Rufino
%A Piris, Miguel A.
%T Peripheral T-cell lymphoma: molecular profiling recognizes subclasses and identifies prognostic markers
%D 2021
%@ 2473-9529
%U https://hdl.handle.net/10668/25153
%X Peripheral T-cell lymphoma (PTCL) is a clinically aggressive disease, with a poor response to therapy and a low overall survival rate of approximately 30% after 5 years. We have analyzed a series of 105 cases with a diagnosis of PTCL using a customized NanoString platform (NanoString Technologies, Seattle, WA) that includes 208 genes associated with T-cell differentiation, oncogenes and tumor suppressor genes, deregulated pathways, and stromal cell subpopulations. A comparative analysis of the various histological types of PTCL (angioimmunoblastic T-cell lymphoma [AITL]; PTCL with T follicular helper [TFH] phenotype; PTCL not otherwise specified [NOS]) showed that specific sets of genes were associated with each of the diagnoses. These included TFH markers, cytotoxic markers, and genes whose expression was a surrogate for specific cellular subpopulations, including follicular dendritic cells, mast cells, and genes belonging to precise survival (NF-kappa B) and other pathways. Furthermore, the mutational profile was analyzed using a custom panel that targeted 62 genes in 76 cases distributed in AITL, PTCL-TFH, and PTCL-NOS. The main differences among the 3 nodal PTCL classes involved the RHOA(G)(17V) mutations (P
%K Expression
%K Survival
%K Mutation
%~