RT Journal Article T1 Desired weight loss and its association with health, health behaviors and perceptions in an adult population with weight excess: One-year follow-up. A1 Bouzas, Cristina A1 Bibiloni, Maria Del Mar A1 Garcia, Silvia A1 Mateos, David A1 Martinez-Gonzalez, Miguel Angel A1 Salas-Salvado, Jordi A1 Corella, Dolores A1 Goday, Albert A1 Martinez, J Alfredo A1 Alonso-Gomez, Angel M A1 Wärnberg, Julia A1 Vioque, Jesus A1 Romaguera, Dora A1 Lopez-Miranda, Jose A1 Estruch, Ramon A1 Tinahones, Francisco J A1 Lapetra, Jose A1 Serra-Majem, Lluis A1 Riquelme-Gallego, Blanca A1 Martin-Sanchez, Vicente A1 Pinto, Xavier A1 Gaforio, Jose J A1 Matia, Pilar A1 Vidal, Josep A1 Vazquez, Clotilde A1 Daimiel, Lidia A1 Ros, Emilio A1 Pascual-Roquet-Jalmar, Elena A1 Babio, Nancy A1 Gonzalez-Monge, Inmaculada A1 Castañer, Olga A1 Abete, Itziar A1 Sorto-Sanchez, Carolina A1 Carlos Benavente-Marin, Juan A1 Torres-Collado, Laura A1 Martin, Marian A1 Garcia-Rios, Antonio A1 Castro-Barquero, Sara A1 Fernandez-Garcia, Jose C A1 Santos-Lozano, Jose Manuel A1 Fernandez-Lazaro, Cesar I A1 Salas-Huetos, Albert A1 Guillem-Saiz, Patricia A1 Zomeño, Maria Dolores A1 Angeles Zulet, Maria A1 Goikoetxea-Bahon, Amaia A1 Gea, Alfredo A1 Nishi, Stephanie K A1 Schröder, Helmut A1 Tur, Josep A A1 PREDIMED-Plus investigators, K1 Mediterranean diet K1 PREDIMED-plus trial K1 desired weight loss K1 health perception K1 metabolic syndrome AB Metabolic syndrome (MetS) worsens quality of life and increases mortality. Dissatisfaction with weight in patients with MetS may modify the effect of lifestyle interventions to achieve changes in health-related behaviors. To assess 1-year changes in cardiovascular risk scores, self-perceived general health and health-related behaviors according to observed changes in desired weight loss during the first year of intervention in a large cardiovascular prevention trial. Prospective analysis of the PREDIMED-PLUS trial, including 5,499 adults (55-75 years old) with overweight or obesity at baseline. The desired weight loss was the difference between ideal and measured weight. Tertiles of change in desired weight loss (1 year vs. baseline) were defined by the following cut-off points: ≥0.0 kg (T1, n = 1,638); 0.0 to -4.0 kg (T2, n = 1,903); ≤-4.0 kg (T3, n = 1,958). A food frequency questionnaire assessed diet and the Minnesota-REGICOR questionnaire assessed physical activity. The Framingham equation assessed cardiovascular risks. The changes in the severity of MetS were also assessed. The Beck Depression Inventory assessed depressive symptoms and the SF-36 assessed health-related quality of life. Data were analyzed using general linear models. BMI decreased at T2 and T3 (T1: 0.3, T2: -0.7, T3: -1.9). The most significant improvement in diet quality was observed at T3. Cardiovascular risk decreased at T2 and T3. Mean reductions in MetS severity score were: -0.02 at T1, -0.39 at T2 and -0.78 at T3. The perception of physical health increases in successive tertiles. In older adults with MetS, more ambitious desired weight loss goals were associated with improvements in diet, cardiovascular health and perceived physical health during the first year of a healthy lifestyle intervention programme. Weight dissatisfaction needs to be considered by health professionals. http://www.isrctn.com/ISRCTN89898870, identifier 89898870. SN 2296-861X YR 2022 FD 2022-07-22 LK http://hdl.handle.net/10668/20659 UL http://hdl.handle.net/10668/20659 LA en NO Bouzas C, Bibiloni MDM, Garcia S, Mateos D, Martínez-González MÁ, Salas-Salvadó J, et al.; PREDIMED-Plus investigators. Desired weight loss and its association with health, health behaviors and perceptions in an adult population with weight excess: one-year follow-up. Front Nutr. 2022 Jul 22;9:848055 NO We especially thank the PREDIMED-Plus participants for their enthusiastic collaboration, the PREDIMED-Plus personnel for outstanding support and the personnel of all associated primary care centres for their exceptional effort. CIBEROBN, CIBERESP, and CIBERDEM are initiatives of Instituto de Salud Carlos III, Spain. We also thank the PREDIMED-Plus Biobank Network, part of the National Biobank Platform of Instituto de Salud Carlos III for storing and managing biological samples. DS RISalud RD Apr 19, 2025