RT Journal Article
T1 Health related quality of life following open versus minimally invasive total gastrectomy for cancer: Results from a randomized clinical trial.
A1 van der Wielen, Nicole
A1 Daams, Freek
A1 Rosati, Riccardo
A1 Parise, Paolo
A1 Weitz, Jürgen
A1 Reissfelder, Christoph
A1 Diez Del Val, Ismael
A1 Loureiro, Carlos
A1 Parada-González, Purificación
A1 Pintos-Martínez, Elena
A1 Vallejo, Francisco Mateo
A1 Achirica, Carlos Medina
A1 Sánchez-Pernaute, Andrés
A1 Campos, Adriana Ruano
A1 Bonavina, Luigi
A1 Asti, Emanuele L G
A1 Poza, Alfredo Alonso
A1 Gilsanz, Carlos
A1 Nilsson, Magnus
A1 Lindblad, Mats
A1 Gisbertz, Suzanne S
A1 van Berge Henegouwen, Mark I
A1 Romario, Uberto Fumagalli
A1 De Pascale, Stefano
A1 Akhtar, Khurshid
A1 Bonjer, H Jaap
A1 Cuesta, Miguel A
A1 van der Peet, Donald L
A1 Straatman, Jennifer
K1 Gastric cancer
K1 Minimally invasive gastrectomy
K1 Open gastrectomy
K1 Quality of life
AB Minimally invasive techniques show improved short-term and comparable long-term outcomes compared to open techniques in the treatment of gastric cancer and improved survival has been seen with the implementation of multimodality treatment. Therefore, focus of research has shifted towards optimizing treatment regimens and improving quality of life. A randomized trial was performed in thirteen hospitals in Europe. Patients were randomized between open total gastrectomy (OTG) or minimally invasive total gastrectomy (MITG) after neoadjuvant chemotherapy. This study investigated patient reported outcome measures (PROMs) on health-related quality of life (HRQoL) following OTG or MITG, using the Euro-Qol-5D (EQ-5D) and the European Organization for Research and Treatment of Cancer (EORTC) questionnaires, modules C30 and STO22. Due to multiple testing a p-value  Between January 2015 and June 2018, 96 patients were included in this trial. Forty-nine patients were randomized to OTG and 47 to MITG. A response compliance of 80% was achieved for all PROMs. The EQ5D overall health score one year after surgery was 85 (60-90) in the open group and 68 (50-83.8) in the minimally invasive group (P = 0.049). The median EORTC-QLQ-C30 overall health score one year postoperatively was 83,3 (66,7-83,3) in the open group and 58,3 (35,4-66,7) in the minimally invasive group (P = 0.002). This was not statistically significant. No differences were observed between open total gastrectomy and minimally invasive total gastrectomy regarding HRQoL data, collected using the EQ-5D, EORTC QLQ-C30 and EORTC-QLQ-STO22 questionnaires.
YR 2021
FD 2021-08-30
LK http://hdl.handle.net/10668/22192
UL http://hdl.handle.net/10668/22192
LA en
DS RISalud
RD Apr 11, 2025